18778-38-6

Basic information

• Product Name: 2,3,4'-trimethoxy-chalcone
• Synonyms: 2,3,4'-trimethoxy-chalcone
• CAS NO: 18778-38-6
• Molecular Weight: 298.339
• Mol File: 18778-38-6.mol

Chemical Properties

• CAS DataBase Reference: 2,3,4'-trimethoxy-chalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4'-trimethoxy-chalcone(18778-38-6)
• EPA Substance Registry System: 2,3,4'-trimethoxy-chalcone(18778-38-6)

Safety Data

• Hazardous Substances Data: 18778-38-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3,4'-Trimethoxy-chalcone is used as a therapeutic agent for its potential anticancer properties, targeting the inhibition of cancer cell growth. It is also utilized for its anti-inflammatory effects, which can be beneficial in managing inflammatory conditions.
Used in Diabetes Management:
In the field of diabetes treatment, 2,3,4'-trimethoxy-chalcone is used as an antidiabetic agent, leveraging its demonstrated ability to improve glycemic control and insulin sensitivity in animal studies, suggesting its potential to contribute to diabetes management in humans.
Used in Neurodegenerative Disease Treatment:
2,3,4'-Trimethoxy-chalcone is employed as a neuroprotective agent in the context of neurodegenerative diseases, due to its potential to protect neurons and mitigate disease progression, offering hope for the development of treatments for conditions such as Alzheimer's and Parkinson's diseases.

Upstream product

• 77-78-1 dimethyl sulfate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 86-51-1 2,3-dimethyoxybenzaldehyde 

Downstream Products

• 114278-31-8 6-(2,3-dimethoxy-phenyl)-4-(4-methoxy-phenyl)-2-oxo-cyclohex-3-enecarboxylic acid ethyl ester 

Relevant articles and documents

New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors

Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N′-(1,3-disubstitutedphenylallylidene)-2-(5-substituted-2-benzoxazolinone-3-yl)acetohydrazide skeleton wer

Biological evaluation and synthesis of new pyrimidine-2(1H)-ol/-thiol derivatives derived from chalcones using the solid phase microwave method

Twenty-five new hydroxy- and methoxy-substituted 4,6-diarylpyrimidin-2(1H)-ol (20–34) and 4,6-diarylpyri-midine-2(1H)-thiol derivatives (35–44) were synthesized from the reaction of the corresponding 1,3-diaryl-2-propene-1-one compounds (1–19) with urea or thiourea using the solid-phase microwave method. All the new synthetic compounds (20–44) were evaluated with regard to their α-glucosidase activity. However, only compounds 22–25, 27, 31, 34, 35, 37, and 40 exhibited a greater inhibitory effect than standard acarbose. The IC50 values of the active compounds ranged between 2.36 and 13.34 μM. The 25 new compounds were also screened for their in vitro pancreatic lipase activity and compounds 20–27 and 35–39 were found to be active. Of these compounds 26, 27, and 39 exhibited the best antilipase activities at concentrations of 0.40 ± 0.06, 0.26 ± 0.07, and 0.29 ± 0.026 μM. All the new compounds (20–44) were evaluated for their in vitro antimicrobial activity for nine test microorganisms. Compounds 20–24 and 35–39 were determined to possess a significant broad spectrum against the gram-positive bacteria Escherichia faecalis, Staphylococcus aureus, and Bacillus cereus among the tested bacterial agents. Compounds 20–24 and 35–39 exhibit the best activity against Mycobacterium smegmatis, with minimum inhibitory concentrations of 62.5–500 μg/mL, indicating their potential use as antituberculous agents.