187791-77-1Relevant academic research and scientific papers
A diastereoselective radical cyclisation approach to pyroglutamates
Goodall, Karen,Parsons, Andrew F.
, p. 491 - 494 (1997)
The 5-endo radical cyclisation of pyruvic acid derived dehydroalanines which contain chiral ester auxiliaries is reported. Cyclisation of the menthol ester derivative using Bu3SnH at 80°C proceeded with low diastereoselectivity (1.75:1) but the selectivity could be increased to 6:1 on cyclisation of the corresponding 8-phenylmenthyl ester at 20°C.
