187795-82-0

Upstream product

• 187795-81-9 4-(2'-bromo-3',4',5'-trimethoxyphenyl)-2-butanone 
• 109-77-3 malononitrile 
• 81925-35-1 2-bromo-3,4,5-trimethoxybenzyl bromide 

Downstream Products

• 187795-83-1 2-amino-5-(2'-bromo-3',4',5'-trimethoxybenzyl)-4-methylthiophene-3-carbonitrile 

Relevant academic research and scientific papers

Brominated trimetrexate analogues as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Five previously undescribed trimetrexate analogues with bulky 2'-bromo substitution on the phenyl ring were synthesized in order to assess the effect of this structure modification on dihydrofolate reductase inhibition. Condensation of 2-[2-(2-bromo-3,4,5