1878-65-5

Basic information

• Product Name: 3-Chlorophenylacetic acid
• Synonyms: 3-Chloropnenylacetic Acid;3-Chlorophenylacetic acid, 98%+;3-Chlorophenylacetic acid, 99+%;3-chlorophenylacetic;m-Chlorophenylacetic;3-Chlorophenylacetic acid 98%;3-Chlorphenylessigsαure;2-(3-chlorophenyl)acetic acid
• CAS NO: 1878-65-5
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• EINECS: 217-520-0
• Product Categories: Phenylacetic acid series;Aromatic Phenylacetic Acids and Derivatives;C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 1878-65-5.mol
• Article Data: 23

Chemical Properties

• Melting Point: 76-79 °C(lit.)
• Boiling Point: 241.44°C (rough estimate)
• Flash Point: 131.7 °C
• Appearance: White/Shiny Flakes and Chunks
• Density: 1.2315 (rough estimate)
• Vapor Pressure: 0.000751mmHg at 25°C
• Refractive Index: 1.5660 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: methanol: 0.1 g/mL, clear, colorless
• PKA: 4.14(at 25℃)
• BRN: 2045103
• CAS DataBase Reference: 3-Chlorophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chlorophenylacetic acid(1878-65-5)
• EPA Substance Registry System: 3-Chlorophenylacetic acid(1878-65-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1878-65-5(Hazardous Substances Data)

Usage

Chemical Properties

WHITE SHINY FLAKES AND CHUNKS

Purification Methods

Crystallise the acid from EtOH/water, or as needles from *C6H6 or H2O (charcoal). The acid chloride (prepared by boiling with SOCl2) has b 127-129o/15mm. [Dippy & Williams J Chem Soc 161 1934, Misra & Shukla J Indian Chem Soc 28 480 1951, Beilstein 9 III 2263, 9 IV 1674.]

InChI:InChI=1/C8H7ClO2/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4H,5H2,(H,10,11)/p-1

Upstream product

• 201230-82-2 carbon monoxide 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 108-41-8 1-chloro-3-methylbenzene 
• 14062-29-4 ethyl 2-(3-chlorophenyl)acetate 
• 625-99-0 3-iodochlorobenzene 
• 64-19-7 acetic acid 
• 124-38-9 carbon dioxide 
• 306773-38-6 3-chlorobenzaldehyde hydrazone 
• 766-80-3 1-bromomethyl-3-chlorobenzene 
• 81447-63-4 5-chlorobicyclo[4.2.0]octa-1,3,5-trien-7-one 
• 14338-36-4 3-amino phenylacetic acid 
• 766-83-6 m-chlorophenylacetylene 
• 114980-29-9 1-chloro-3-(2,2,2-trichloroethyl)benzene 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 72116-91-7 (3-chloro-phenyl)-acetic acid-(4-chloro-anilide) 
• 72116-94-0 (3-chloro-phenyl)-acetic acid p-anisidide 
• 72116-64-4 (3-chloro-phenyl)-acetic acid-(3-chloro-anilide) 
• 53088-68-9 methyl 3-chlorophenylacetate 
• 5182-44-5 2-(3-chlorophenyl)ethanol 
• 22535-07-5 (3-Chlor-phenyl)-acetylbromid 
• 138356-74-8 2-(3-Chloro-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide 
• 106-49-0 p-toluidine 
• 33709-41-0 3-Chlor-1-<2-acetoxy-ethyl>-benzol 
• 56988-12-6 C₁₅H₁₀ClNO₄ 
• 19055-77-7 2-(3'-Chlorphenyl)-5-methyl-1,3-indandion 
• 21922-62-3 3-Chlor-phenylessigsaeure-N-<2-(3,4-dimethoxyphenyl)-ethylamid> 
• 27396-17-4 tert.-Butyl-m-chlorphenylperacetat 

Relevant articles and documents

An improved method for the synthesis of phenylacetic acid derivatives via carbonylation

2,4-Dichlorophenylacetic acid is synthesized in high yield via the carbonylation of 2,4-dichlorobenzyl chloride, and various experimental conditions are evaluated. Xylene, bistriphenylphosphine palladium dichloride, tetraethylammonium chloride and sodium hydroxide in solution are added to the reaction system and held at 80 °C under a CO atmosphere. 2,4-Dichlorophenylacetic acid is obtained in a maximum yield of 95percent, and a mechanism for 2,4-dichlorobenzyl chloride carbonylation is proposed. The reaction system provides a mild, effective and novel means by which to prepare phenylacetic acid derivatives from their corresponding benzyl chloride derivatives.

Preparation method of phenylacetic acid type compound

The invention discloses a preparation method of a phenylacetic acid type compound. The preparation method of the phenylacetic acid type compound I comprises the following steps that in a solvent and aCO gas phase system, a benzyl halide type compound II, pyridine-2-cobalt carboxylate, palladium acetate and alkaline neutralizers take carbonylation reaction to obtain the phenylacetic acid type compound I. A mixed catalytic system has a synergistic effect; the whole use quantity of catalysts is greatly reduced. When the mixed catalyst is used, a better catalytic effect can be achieved; the characteristics of easily obtaining the catalyst, avoiding the production safety risk of toxic three wastes and the like, reducing the reaction pressure, realizing mild reaction conditions, reducing the production risk, facilitating the production and the like are realized. The formulas are shown in description.

The selenium-containing complexes in the phenylacetic acid and its derivatives or its application in the synthesis of (by machine translation)

The present invention provides a kind of structural formula (I) indicated by the 2 - (2 - carboxyl phenyl) benzothiazole of selenium-containing complexes of, this kind of selenium-containing complex can be applied to the catalytic benzyl chloride rigid synthetic phenylacetic acid or derivatives thereof in the reaction, in the reaction, the less the amount of catalyst, the catalytic activity is high, simple operation, conducive to such synthetic method in industry popularization and application. (by machine translation)