18780-48-8

Upstream product

• 2392-54-3 (acetyl-methyl-amino)-phenyl-acetic acid 
• 14533-86-9 methyl (E)-2-cyano-3-phenylprop-2-enoate 
• 86296-98-2 3-Cyano-1,5-dimethyl-2,4-diphenyl-2,3-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 81156-07-2 4,5-dimethyl-2-phenyl-1,3-oxazolium-5-olate 
• 72726-10-4 2,3-dimethyl-4-phenyloxazolium-5-olate 

Relevant academic research and scientific papers

Regioselectivity in the 1,3-dipolar cycloaddition of muenchnones with two electrophilic alkynes. Attempt of rationalization.

The 1,3-dipolar cycloaddition reaction of several unsymmetrically substituted muenchnones with methyl propiolate 3a and with methyl 3-phenylpropiolate 3b has been examined.The reaction generally proceeds with formation of mixtures of both possible regioisomeric pyrroles.The dipolarophile 3b is more selective than 3a in accordance with the literature.Sustmann's variation-perturbation theory could not account for the observed regioselectivities, this theory gives correct predictions with alkenes as we have shown recently. 1,3-cycloaddition / muenchnones / pyrroles / regioselectivity