187805-54-5

Basic information

• Product Name: Benzamide, 2-amino-3-fluoro- (9CI)
• Synonyms: Benzamide, 2-amino-3-fluoro- (9CI);2-aMino-3-fluorobenzaMide
• CAS NO: 187805-54-5
• Molecular Formula: C₇H₇FN₂O
• Molecular Weight: 154.1416832
• Product Categories: HALIDE;AMIDE
• Mol File: 187805-54-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzamide, 2-amino-3-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-amino-3-fluoro- (9CI)(187805-54-5)
• EPA Substance Registry System: Benzamide, 2-amino-3-fluoro- (9CI)(187805-54-5)

Safety Data

• Hazardous Substances Data: 187805-54-5(Hazardous Substances Data)

Usage

General Description

Benzamide, 2-amino-3-fluoro- (9CI) is a chemical compound with the formula C7H7FN2O. It is a fluoro-substituted derivative of benzamide, which is a white solid with a faint odor. Benzamide, 2-amino-3-fluoro- (9CI) is commonly used in organic synthesis and pharmaceutical research due to its potential pharmacological and biological activities. Its specific applications include as a pharmaceutical intermediate and as a building block for the synthesis of various biologically active molecules. Additionally, it has been studied as a potential inhibitor of enzymes and as a source of fluorine in medicinal chemistry. Overall, benzamide, 2-amino-3-fluoro- (9CI) has various potential industrial and research applications.

Upstream product

• 317-20-4 7-fluoro-1H-indole-2,3-dione 
• 825-22-9 3-fluoroanthranilic acid 
• 2592-95-2 benzotriazol-1-ol 

Downstream Products

• 1295570-35-2 C₇H₆BrFN₂O 

Relevant articles and documents

Acid-Catalyzed Synthesis of Isatoic Anhydride-8-Secondary Amides Enables IASA Transformations for Medicinal Chemistry

Quinazolin-dione-N-3-alklyl derivatives are the core scaffolds for several categories of bioactive small molecules, but current synthetic methods are costly, involve environmental hazards, and are not uniformly scalable. Here, we report an inexpensive, flexible, and scalable method for the one-pot synthesis of substituted quinazolin-dione-N-3-alkyls (isomers of isatoic-8-secondary amides (IASAs)) from isatin that take advantage of in situ capture of imidic acid under acidic conditions. We further show that this method can be used for the synthesis of a wide variety of derivatives with medicinal uses.

Oxidative ring-opening of isatins for the synthesis of 2-aminobenzamides and 2-aminobenzoates

An efficient and practical isatin-based oxidative domino protocol has been developed for the facile synthesis of 2-aminobenzamides and 2-aminobenzoates. The robust nature of this reaction system is reflected by accessible starting materials, room temperature and high-yield gram-scale synthesis.

POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS

The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.