187806-33-3Relevant academic research and scientific papers
The continuous-flow synthesis of carbazate hydrazones using a simplified computer-vision controlled liquid–liquid extraction system
O'Brien, Matthew,Cooper, Dennis A.,Mhembere, Panashe
supporting information, p. 5188 - 5191 (2016/11/13)
A computer-vision controlled liquid–liquid extraction system was used in the continuous-flow synthesis of a series of carbazate hydrazones. The system uses open-source software components (Python, OpenCV) and is simpler and potentially more economical, in terms of hardware, than one we have described previously.
Identification of novel pyrazole acid antagonists for the EP1 receptor
McKeown, Stephen C.,Hall, Adrian,Giblin, Gerard M.P.,Lorthioir, Olivier,Blunt, Richard,Lewell, Xiao Q.,Wilson, Richard J.,Brown, Susan H.,Chowdhury, Anita,Coleman, Tanya,Watson, Stephen P.,Chessell, Iain P.,Pipe, Adrian,Clayton, Nick,Goldsmith, Paul
, p. 4767 - 4771 (2007/10/03)
The discovery, synthesis and structure-activity relationship (SAR) of a novel series of EP1 receptor antagonists is described. Pyrazole acid 4, identified from a chemical array, had desirable physicochemical properties, an excellent in vitro microsomal inhibition and cytochrome P450 (CYP450) profile and good exposure levels in blood. This compound had an ED50 of 1.3 mg/kg in a rat pain model. A range of more potent analogues in the in vitro assay was identified using efficient array chemistry. These EP1 antagonists have potential as agents in the treatment of PGE2 mediated pain.
