187831-22-7

Usage

Uses

Used in Organic Synthesis:
(+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol is used as a chiral building block for the synthesis of various organic compounds. Its unique structure allows for the creation of enantiomerically pure products, which are essential in many chemical reactions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol is employed as a key intermediate in the development of pharmaceuticals. Its chiral properties make it a crucial component in the synthesis of drugs with specific therapeutic effects.
Used in Pharmaceutical Production:
(+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol is utilized as an intermediate in the manufacturing process of various pharmaceuticals. Its presence in the synthesis contributes to the development of effective and targeted treatments.
Used in Agrochemical Production:
(+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol also finds application in the production of agrochemicals, where it serves as an intermediate in the synthesis of pesticides and other agricultural products. Its role in these processes helps to create more effective and targeted agrochemicals for crop protection and enhancement.
Used in the Development of New Chemical Processes:
(+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol is a valuable tool for researchers in the development of innovative chemical processes. Its unique structure and properties allow for the exploration of new reaction pathways and the creation of novel compounds with potential applications across various industries.

Upstream product

• 64488-52-4 N-[4-(2-chloro-1-oxoethyl)phenyl]methanesulfonamide 
• 108-22-5 Isopropenyl acetate 
• 124486-72-2 (+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol 
• 1197-22-4 N-phenylmethanesulfonamide 
• 62-53-3 aniline 

Relevant academic research and scientific papers

'Green' synthesis of important pharmaceutical building blocks: Enzymatic access to enantiomerically pure α-chloroalcohols

Thirty one recombinant ketoreductase enzymes were screened for the reduction of six α-chloroketones, the precursors of pharmaceutically valuable α-chloroalcohols. Several highly active and enantioselective ketoreductases were found and their applications

Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol

Synthesis of both enantiomers of biologically active propranolol and sotalol has been achieved in high optical purity by one-pot reduction of 3 and 7 followed by in situ lipase resolution of the respective chlorohydrins. Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) provided the chlorohydrin and acetate, which on nucleophilic substitution with isopropyl amine afforded the target amino alcohols in high enantioselectivity under mild reaction conditions.

A practical synthesis of optically active aromatic epoxides via asymmetric transfer hydrogenation of α-chlorinated ketones with chiral rhodium-diamine catalyst

A practical method for the synthesis of optically active aromatic epoxides has been developed via the formation of optically active α-chlorinated alcohols and intramolecular etherification. Optically active alcohols with up to 99% ee can be obtained from

PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOHYDRIN COMPOUND

A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an α-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.

Practical synthesis of optically active styrene oxides via reductive transformation of 2-chloroacetophenones with chiral rhodium catalysts

(equation presented) A practical method for the synthesis of optically active styrene oxides has been developed via formation of optically active 2-chloro-1-phenylethanols generated by reductive transformation of ring-substituted 2-chloroacetophenones. Th

anti-Prelog microbial reduction of aryl α-halomethyl or α- hydroxymethyl ketones with Geotrichum sp. 38

Reduction of aryl α-halomethyl ketones 5a-d and 7a-h and α- hydroxymethyl ketones 10a-b by Geotrichum sp. 38 affording mostly the anti- Prelog alcohols was reported and the stereoselectivities of the reductive products were discussed.

Biocatalytic synthesis of some chiral drug intermediates by oxidoreductases

Chiral intermediates were prepared by biocatalytic processes with oxidoreductases for the chemical synthesis of some pharmaceutical drug candidates. These include: (i) the microbial reduction of 1-(4-fluorophenyl)-4-[4-(5-fluoro-2-pyrimidinyl)-1 -piperazi