187835-15-0Relevant academic research and scientific papers
Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1′ permutations
Burns, David M.,He, Chunhong,Li, Yanlong,Scherle, Peggy,Liu, Xiangdong,Marando, Cindy A.,Covington, Mayanne B.,Yang, Gengjie,Pan, Max,Turner, Sharon,Fridman, Jordan S.,Hollis, Gregory,Vaddi, Kris,Yeleswaram, Swamy,Newton, Robert,Friedman, Steve,Metcalf, Brian,Yao, Wenqing
, p. 560 - 564 (2008/09/16)
A series of β-sulfonamide piperidine hydroxamates were prepared and shown to be potent inhibitors of the human epidermal growth factor receptor-2 (HER-2) sheddase with excellent selectivity against MMP-1, -2, -3, and -9. This was achieved by exploiting su
