187940-02-9

Basic information

• Product Name: 4-(3,4-dihydro-6,7-dimethoxy-1H-isochromen-1-yl)benzonitrile
• Synonyms: 4-(3,4-dihydro-6,7-dimethoxy-1H-isochromen-1-yl)benzonitrile
• CAS NO: 187940-02-9
• Molecular Weight: 295.338
• Mol File: 187940-02-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(3,4-dihydro-6,7-dimethoxy-1H-isochromen-1-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-dihydro-6,7-dimethoxy-1H-isochromen-1-yl)benzonitrile(187940-02-9)
• EPA Substance Registry System: 4-(3,4-dihydro-6,7-dimethoxy-1H-isochromen-1-yl)benzonitrile(187940-02-9)

Safety Data

• Hazardous Substances Data: 187940-02-9(Hazardous Substances Data)

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 

Downstream Products

• 187940-04-1 [2-(4-Cyano-benzoyl)-4,5-dimethoxy-phenyl]-acetic acid 
• 187940-10-9 4-(7,8-Dimethoxy-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-1-yl)-benzonitrile 

Relevant articles and documents

Heteropolyacid ionic liquid heterogeneously catalyzed synthesis of isochromansviaoxa-Pictet-Spengler cyclization in dimethyl carbonate

A recyclable and efficient heterogeneous, green catalyst based on the synthesis of Keggin-type polyoxometalate (H3PMo12O40) and vitamin B1 analogue 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium (HEMT),i.e., [HEMTH]H2[PMo12O40] was prepared. Oxa-Pictet-Spengler cyclization of arylethanols and aldehydes were catalyzed to afford various substituted isochromans in moderate conditions with excellent yields using dimethyl carbonate (DMC) as a green solvent. Furthermore, this protocol was applicable in a gram-scale reaction, and the catalyst could be recycled eight times without significant loss of activity.

Silica-supported policresulen as a solid acid catalyst for organic reactions

A new type of solid catalyst was prepared by coating a thin layer of policresulen, an inexpensive polymer prepared via condensation of 2-hydroxy-4-methylbenzenesulfonic acid and formaldehyde that has been used as commercially available drug, onto the surface of silica. The policresulen component is insoluble in many organic solvents and can be adsorbed on silica with the aid of hydrogen bonding. The obtained silica/policresulen composite showed remarkable catalytic activity for various organic reactions. In model reactions, the catalyst can be recycled several times without significant loss of activity. The salient features of using this acid catalyst in organic reactions include cost-effectiveness, simple and time-efficient preparation, and the convenience of controlling the acid loading on the solid.

Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

2,3-Benzodiazepines represent a class of heterocyclic compounds that interact with AMPA-type glutamate receptors in a noncompetitive manner. These compounds have attracted great interest for their pharmacological effects against acute and chronic neurodeg