187964-44-9

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 98-80-6 phenylboronic acid 
• 113388-94-6 1-phenyl-3,4-dihydro-naphthalene-2-carbaldehyde 
• 117582-62-4 1-bromo-2-formyl-3,4-dihydronaphthalene 
• 108-86-1 bromobenzene 

Downstream Products

• 161950-64-7 2-hydroxymethyl-1-phenylnaphthalene 
• 883221-16-7 (1-phenyl-3,4-dihydronaphthalen-2-yl)methyl acetate 

Relevant academic research and scientific papers

Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones

α-Tetralones were initially converted into 1-bromo- dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2-carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes.

N-phenylamide and N-pyridylamide derivatives, method of preparing them and pharmaceutical compositions containing them

The present invention relates to the compounds of formula (I) in which X, R1, R2 and R3are as defined in claim 1. These compounds are cholesteryl acyl transferase (ACAT) inhibitors.