187975-62-8

Basic information

• Product Name: (S)-4-(4-Hydrazinylbenzyl)-2-oxazolidinone
• Synonyms: (S)-4-(4-Hydrazinylbenzyl)-2-oxazolidinone;(4S)-4-[(4-hydrazinylphenyl)Methyl]-2-Oxazolidinone;Zolmitriptan Impurity 1
• CAS NO: 187975-62-8
• Molecular Formula: C₁₀H₁₃N₃O₂
• Molecular Weight: 207
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 187975-62-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 519.346°C at 760 mmHg
• Flash Point: 267.891°C
• Appearance: /
• Density: 1.318g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: Refrigerator
• Solubility: Dimethylformamide
• CAS DataBase Reference: (S)-4-(4-Hydrazinylbenzyl)-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(4-Hydrazinylbenzyl)-2-oxazolidinone(187975-62-8)
• EPA Substance Registry System: (S)-4-(4-Hydrazinylbenzyl)-2-oxazolidinone(187975-62-8)

Safety Data

• Hazardous Substances Data: 187975-62-8(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase.

InChI:InChI=1/C10H13N3O2/c11-13-8-3-1-7(2-4-8)5-9-6-15-10(14)12-9/h1-4,9,13H,5-6,11H2,(H,12,14)/t9-/m1/s1

Upstream product

• 152305-23-2 (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one 

Downstream Products

• 139264-17-8 zolmitriptan 
• 139264-57-6 (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride 
• 171549-95-4 {3-[5-(2-oxo-oxazolidin-4-ylmethyl)-1H-indol-3-yl]-cyclobutyl}-carbamic acid benzyl ester 
• 139264-15-6 (S)-2-<5-<(2-oxo-1,3-oxazolidin-4-yl)methyl>-1H-indol-3-yl>ethylamine 

Relevant articles and documents

PROCESS FOR PREPARATION OF ZOLMITRIPTAN

The present invention provides a convenient and industrially viable process for preparation of Zolmitriptan (I) having desired purity. The invention specifically relates to a method for isolating (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride (IIIa) of desired purity by separating the undesired inorganic side products such as stannous hydroxide by manipulation of pH at different stages and finally treating with N,N-dimethylamino butyraldehyde diethyl acetal in an acidic medium to provide Zolmitriptan (I) conforming to regulatory specifications.

PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF

The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient zolmitriptan. In particular, it relates to an efficient process for the preparation of zolmitriptan and its pharmaceutically acceptable salts and solvates.

PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF

The present invention relates to an improved process for the preparation of the activepharmaceutical ingredient zolmitriptan. In particular, it relates to an efficient process for the preparation of zolmitriptan and its pharmaceutically acceptable salts and solvates.