188009-13-4

Basic information

• Product Name: 2-(3-Cyclopentyloxy-4-Methoxy-phenyl)-4-phenyl-but-3-ynylaMine hydrochloride
• Synonyms: 2-(3-Cyclopentyloxy-4-Methoxy-phenyl)-4-phenyl-but-3-ynylaMine hydrochloride;2-(3-(Cyclopentyloxy)-4-Methoxyphenyl)-4-phenylbut-3-yn-1-aMine hydrochloride
• CAS NO: 188009-13-4
• Molecular Formula: C22H26ClNO2
• Molecular Weight: 371.90034
• Mol File: 188009-13-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(3-Cyclopentyloxy-4-Methoxy-phenyl)-4-phenyl-but-3-ynylaMine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Cyclopentyloxy-4-Methoxy-phenyl)-4-phenyl-but-3-ynylaMine hydrochloride(188009-13-4)
• EPA Substance Registry System: 2-(3-Cyclopentyloxy-4-Methoxy-phenyl)-4-phenyl-but-3-ynylaMine hydrochloride(188009-13-4)

Safety Data

• Hazardous Substances Data: 188009-13-4(Hazardous Substances Data)

Usage

Derived from

Phenylalanine

Contains

Phenyl and cyclopentyloxy group

Receptor interaction

Selective antagonist for the opioid receptor kappa-1

Role

Involved in pain sensation and addiction

Potential applications

Treatment of pain and addiction-related disorders

Salt form

Hydrochloride (enhances stability and solubility)

Suitability

Pharmaceutical formulations

Current status

Ongoing research on therapeutic uses

Relevant articles and documents

Substituted-pent-4-ynoic acids

PCT No. PCT/US96/11613 Sec. 371 Date Sep. 14, 1998 Sec. 102(e) Date Sep. 14, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/03945 PCT Pub. Date Feb. 6, 1997Compounds of formula (I) wherein: R1 is -(CR4R5)nC(O)O(CR4R5)mR6, -(CR4R5)nC(O)NR4(CR4R5)mR6, (CR4R5)nO(CR4R5)mR6, or -(CR4R5)rR6: W is alkynyl or 2 carbon atoms; R3 is H or R7; Z is C(O)R13, (CH2)0-1C(O)OR13, (CH2)0-1C(O)NR10R13, (CH2)0-1C(R8R8)OR8, -NHC(O)R7, (CH2)0-1NR10R13, NH[C(O)C(O)OR8], CH2NH[C(O)CNR10R13], CH2S(O)qR7, CH[S(O)qR7]2, dithiolane, (tetrazol-5-yl), thiazol-2-yl, [1,2,4]thiadiazol-5-yl, [1,3,4]oxadiazol-2-yl, imidazol-2-yl, oxazol-2-yl, or (3- or 5-oxadiazolyl[1,2,4]; R7 is -(CR4R5)qR11 or C1-6 alkyl wherein the R11 or C1-6 alkyl group is unsubstituted or substituted one or more times by methyl or ethyl unsubstituted or substituted by 1-3 fluorines, -NR8R10, -CO2R8, -O(CH2qR8, -NR8C(O)R8 or R12; or the pharmaceutically acceptable salts thereof.