18802-38-5

Usage

Uses

Used in Plastics Industry:
6-amino-1,2,4-triazine-3,5(2H,4H)-dione is used as a key ingredient in the production of plastics for its ability to enhance the material's heat resistance and durability. Its high nitrogen content contributes to the formation of strong intermolecular bonds, resulting in improved mechanical properties.
Used in Adhesives Industry:
In the adhesives industry, 6-amino-1,2,4-triazine-3,5(2H,4H)-dione is utilized as a component to improve the adhesive's bonding strength and resistance to heat and chemicals. Its high nitrogen content allows for the formation of strong cross-linking networks within the adhesive, leading to enhanced performance.
Used in Flame Retardants Industry:
6-amino-1,2,4-triazine-3,5(2H,4H)-dione is employed as a flame retardant in various applications, such as textiles, plastics, and coatings. Its high nitrogen content and chemical structure enable it to release non-flammable gases during combustion, thereby reducing the flammability of the material.
Used in Dinnerware and Kitchenware Manufacturing:
Melamine is a common ingredient in the production of dinnerware and kitchenware due to its durability, heat resistance, and ease of cleaning. Its chemical stability and resistance to staining make it an ideal material for food contact surfaces.
However, it is important to note that the use of 6-amino-1,2,4-triazine-3,5(2H,4H)-dione in food containers and utensils has raised safety concerns. Ingesting melamine can lead to health complications, and as a result, it is crucial to regulate its use in food safety standards to ensure consumer health and safety.

InChI:InChI=1/C3H4N4O2/c4-1-2(8)5-3(9)7-6-1/h(H2,4,6)(H2,5,7,8,9)

Upstream product

• 4956-05-2 6-bromo-1,2,4-triazine-3,5(2H,4H)-dione 

Downstream Products

• 112394-74-8 N-(3-Hydroxy-5-oxo-2,5-dihydro-[1,2,4]triazin-6-yl)-benzamide 

Relevant academic research and scientific papers

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.

BICYCLIC COMPOUNDS

Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

NEW BICYCLIC COMPOUNDS AS PI3-K AND MTOR INHIBITORS

There is provided compounds of formula (I), wherein A1, A4, A4a, A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.

NEW BICYCLIC COMPOUNDS AS PI3-K AND MTOR INHIBITORS

There is provided compounds of formula (I), wherein A1, A4, A4a,A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.

Synthesis of C-ribosyl imidazo[2,1-f][1,2,4]triazines as inhibitors of adenosine and AMP deaminases

The 3-β-D-ribofuranoside 6 of the new imidazo[2,1-f][1,2,4]triazine 27 is isomeric and isoelectronic with the nucleoside deaminoformycin 1 which is a good inhibitor of adenosine deaminase (ADA) while its 5′-monophosphate 2 is a good inhibitor of adenosine 5′-monophosphate deaminase (AMPDA). The 6-methylsulfanyl derivative 7 of 6 is synthesized by condensation of the monocyclic 1,2,4-triazine 9 with bromo aldehyde 10, which is accompanied by cyclization to give the protected C-nucleoside 21; the 8-methylsulfanyl group of 21 is removed by replacement by hydrazine and oxidation. The 1,2,4-triazine 9 cyclizes similarly with chloroacetaldehyde or its dimethyl acetal to give 6,8-bis(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine 17, which is converted into the parent heterocycle 27 by two routes, and into mono- and di-substituted derivatives (19, 20, 24, 25, 28-30) of the new ring system. Riboside 7 is an inhibitor of mammalian ADA (IC50 40 μM). The Royal Society of Chemistry 1999.