18803-02-6

Basic information

• Product Name: 5-Methoxy-3-phenylisoxazole
• Synonyms: 5-Methoxy-3-phenylisoxazole;3-phenyl-5-methoxyisoxazole
• CAS NO: 18803-02-6
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Mol File: 18803-02-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Methoxy-3-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-3-phenylisoxazole(18803-02-6)
• EPA Substance Registry System: 5-Methoxy-3-phenylisoxazole(18803-02-6)

Safety Data

• Hazardous Substances Data: 18803-02-6(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 7713-79-3 3-phenyl-5-isoxazolone 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 67-56-1 methanol 
• 3356-89-6 3-phenyl-5-chloroisoxazole 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 124-41-4 sodium methylate 
• 60-29-7 diethyl ether 
• 74-88-4 methyl iodide 
• 147726-34-9 (Z)-3-Methoxy-3-methylsulfanyl-1-phenyl-propenone 
• 873-67-6 benzonitrile oxide 
• 6443-91-0 ethynyl methyl ether 

Downstream Products

• 23244-34-0 5-ethoxy-3-phenylisoxazole 
• 27025-89-4 5-i-propyloxy-3-phenylisoxazole 
• 23893-62-1 5-n-butyloxy-3-phenylisoxazole 
• 1403871-58-8 dimethyl 2-[(E)-2-bromo-3-methoxy-3-oxo-1-phenylprop-1-enylimino]malonate 
• 367967-56-4 methyl 2-bromo-3-phenyl-2H-azirine-2-carboxylate 

Relevant articles and documents

4-Alkoxy-3-cyano-2(1H)-pyridones and 5-alkoxyisoxazoles and their aryl substituted and annulated derivatives from acylketene O,S-acetals

The title pyridones 2 and 5 and the isoxazoles 3 and 6 are obtained in moderate to good yields by cyclocondensation of the appropriate acylketene O,S-acetals 1 or 4 with cyanoacetamide and hydroxylamine hydrochloride, respectively, in the presence of sodi

An isoxazole strategy for the synthesis of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates - versatile building blocks for assembling pyrrolo-fused heterocycles

A full atom-economical domino method has been developed for the preparation of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates by transannulation of 5-alkoxyisoxazoles with malononitrile under Fe(ii) catalysis. Alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates are excellent building blocks for various annulation reactions, leading to new derivatives of 1H-pyrrolo[1,2-a]imidazole and pyrrolo[2,3-d]pyrimidine. The DFT calculations of mechanistic details of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylate formation are presented.

A novel strategy for the synthesis of thermally stable and apoptosis-inducing 2,3-dihydroazetes

A general and concise approach to thermally and hydrolytically stable alkyl 2,3-dihydroazete-2,3-di-/2,2,3-tricarboxylates from alkyl 2-bromoazirine-2-carboxylates or 4-bromo-5-alkoxyisoxazoles is reported. The synthesis involves the formation of 2-azabut

Iron dichloride induced isomerization or reductive cleavage of isoxazoles: A facile synthesis of 2-carboxy-azirines

5-Alkoxy-isoxazoles and N,N-disubstituted-5-isoxazolamines were found to isomerize to azirine derivatives by the use of iron dichloride as catalyst. On the contrary 5-alkyl- and 5-aryl-isoxazoles in the presence of the same salt, undergo reductive cleavage to enaminoketones. A common reaction intermediate is proposed.