188047-98-5

Upstream product

• 123-31-9 hydroquinone 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 54974-07-1 phthalimidesulfenyl chloride 
• 108534-47-0 4-(tert-butyldimethylsilyloxy)phenol 

Downstream Products

• 188047-97-4 5-[6-(tert-Butyl-dimethyl-silanyloxy)-2,3-dihydro-benzo[1,4]oxathiin-2-yl]-2-methoxy-phenol 
• 1627688-36-1 C₃₂H₅₄O₄SSi₃ 
• 1616377-37-7 4-(6-hydroxy-2,3-dihydrobenzo[1,4]oxathiin-2-yl)benzene-1,2-diol 
• 865541-53-3 6-(tert-butyl-dimethyl-silanyloxy)-2,3-dihydro-2-(4-methoxy-phenyl)-1,4-benzoxathiin 4,4-dioxide 

Relevant academic research and scientific papers

Thiaflavan scavenges radicals and inhibits DNA oxidation: A story from the ferrocene modification

4-Thiaflavan is a sulfur-substituted flavonoid with a benzoxathiin scaffold. The aim of this work is to compare abilities of sulfur and oxygen atom, hydroxyl groups, and ferrocene moiety at different positions of 4-thiaflavan to trap radicals and to inhibit DNA oxidation. It is found that abilities of thiaflavans to trap radicals and to inhibit DNA oxidation are increased in the presence of ferrocene moiety and are further improved by the electron-donating group attaching to thiaflavan skeleton. It can be concluded that the ferrocene moiety plays the major role for thiaflavans to be antioxidants even in the absence of phenolic hydroxyl groups. On the other hand, the antioxidant effectiveness of phenolic hydroxyl groups in thiaflavans can be improved by the electron-donating group. The influences of sulfur and oxygen atoms in thiaflavans on the antioxidant property of para-hydroxyl group exhibit different manners when the thiaflavans are used to trap radicals and to inhibit DNA oxidation.

Synthesis and "double-faced" antioxidant activity of polyhydroxylated 4-thiaflavans

A simple synthetic methodology, based on the inverse electron demand hetero Diels-Alder reaction of electron-poor dienic o-thioquinones with electron-rich styrenes used as dienophiles, allowed the preparation of several polyhydroxylated 4-thiaflavans. Suc