188048-61-5

Basic information

• Product Name: (S)-2-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
• Synonyms: (S)-2-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
• CAS NO: 188048-61-5
• Molecular Weight: 574.676
• Mol File: 188048-61-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(188048-61-5)
• EPA Substance Registry System: (S)-2-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(188048-61-5)

Safety Data

• Hazardous Substances Data: 188048-61-5(Hazardous Substances Data)

Upstream product

• 962-39-0 L-Phenylalanine benzyl ester 
• 71989-31-6 Fmoc-Pro-OH 

Downstream Products

• 129988-00-7 (S)-2-[((S)-1-Methoxyoxalyl-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester 
• 78746-23-3 Pro-Phe-OBn 

Relevant articles and documents

Synthesis and biological activity of acylated and telomerized peptides as potential HIV-fixation inhibitors

In order to inhibit the gp 120-CD4 glycoprotein interaction, a key step of the HIV-infection, we have synthesized a series of N-acylated peptides containing sequences identified in both the viral and lymphocytic proteins, (SDFR, SDAR, RFDSAARFDS, DRADSRRS, PSKLNDRADSRRSLWD, ASTTTNYT). An hydrophobic moiety (capryloyl, palmitoyl acrylamidoundecanoyl) was introduced in the last step of interative synthesis, in homogeneous or solid phase. The acryloyl-containing compounds were then telomerized under UV irradiation (DPn observed: 2 to 6). The biological evaluation shown an antiviral effect in vitro for telomerized peptides containing amino diacids such as Glu and Asp.