188049-34-5Relevant articles and documents
Synthesis of acyclic nucleotide analogues derived from N-substituted 6-(1-aminoethyl)purines via 6-acetylpurine derivatives
Hocek, Michal,Masojidkova, Milena,Holy, Antonin
, p. 2291 - 2302 (1997)
The Stille coupling of 9-{2-[bis(2-propoxy)phosphonylmethoxy]ethyl}-6-chloropurines with 1-(ethoxyvinyl)tributyltin afforded 6-(1-ethoxyvinyl)purine derivatives. Their acid hydrolysis gave 6-acetylpurine derivatives that after reductive amination using various primary and secondary amine hydrochlorides and sodium cyanoborohydride followed by deprotection afforded the title N-substituted 6-(1-aminoethyl)-9-(2-phosphonomethoxyethyl)purine derivatives.
Benzopiperidine derivatives
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, (2008/06/13)
Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.