188062-43-3

Basic information

• Product Name: ethyl 2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
• CAS NO: 188062-43-3
• Molecular Formula: C₉H₁₀N₄O₃
• Molecular Weight: 222.2007
• Mol File: 188062-43-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 517.234°C at 760 mmHg
• Flash Point: 266.614°C
• Density: 1.688g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.737
• CAS DataBase Reference: ethyl 2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate(188062-43-3)
• EPA Substance Registry System: ethyl 2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate(188062-43-3)

Safety Data

• Hazardous Substances Data: 188062-43-3(Hazardous Substances Data)

Upstream product

• 100643-27-4 2,6-diamino-3H-pyrimidin-4-one 
• 70-23-5 ethyl Bromopyruvate 
• 134288-26-9 3-bromo-2-hydroxyimino-propionic acid ethyl ester 
• 73472-94-3 ethyl 3-bromo-2-(hydroxyimino)propanoate 
• 188062-38-6 3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-2-[(Z)-hydroxyimino]-propionic acid ethyl ester 

Relevant articles and documents

Synthesis of potential inhibitors of GTP-cyclohydrolase I: An efficient synthesis of 8-substituted 7-deazaguanines

A novel two step synthesis of 8-substituted 7-deazaguanines is developed and involves the regioselective alkylation of pyrimidinones 1a and 1b with nitrosoalkenes derived from α-halo oximes followed by transoximation to give the 7-deazaguanines 6a-d in 41

SUBSTITUTED PYRROLO[2,3-D]DIPYRIMIDINES FOR SELECTIVELY TARGETING TUMOR CELLS WITH FR-ALPHA AND FR-BETA TYPE RECEPTORS

Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate receptors (FR) of cancerous tumor cells and inhibit purine synthesis and hence, DNA synthesis.