18810-21-4

Usage

Uses

Used in Respiratory Medicine:
(+)-Isoproterenol hydrochloride is used as a bronchodilator for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It works by relaxing the smooth muscles in the airways, facilitating easier breathing.
Used in Cardiology:
(+)-Isoproterenol hydrochloride is used as a medication for the treatment of bradycardia and heart block. Its positive inotropic and chronotropic effects increase the force and rate of heart contractions, improving cardiac function.
However, due to its non-selective nature, (+)-Isoproterenol hydrochloride can also cause adverse effects such as increased heart rate and blood pressure, tremors, and anxiety. Therefore, its use must be carefully monitored to ensure patient safety and optimal therapeutic outcomes.

Upstream product

• 51-30-9 isoproterenol hydrochloride 
• 120-80-9 benzene-1,2-diol 
• 16899-81-3 Isoproterenone hydrochloride 

Downstream Products

• 51-30-9 isoproterenol hydrochloride 

Relevant academic research and scientific papers

Method for preparing isoproterenol hydrochloride

The invention relates to a method for preparing isoproterenol hydrochloride. The method comprises the following steps: (1) preparation of 2-amino-1-(3, 4-dihydroxy phenyl)-ethanone; (2) preparation of isoproterenol ketone hydrochloride; and (3) preparation of isoproterenol hydrochloride. The method disclosed by the invention adopts a reaction system of glycine and zinc chloride instead of a reaction system of monochloro acetic acid and phosphorus oxychloride, so that the method has the advantages that the environmental protection cost is reduced; the reaction yield is increased; the industrial production is benefited; the reaction condition is mild; the catalyst quantity is little; and the process is simple. Compared with conventional synthetic processes, the method disclosed by the invention has obvious economic benefit and environmental benefit.

Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis

In the present study, hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) were used as additives in capillary electrophoresis for the enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine hydrochloride, isoprenaline hydrochloride, chlorpheniramine maleate, liarozole, tropicamide, amlodipine benzenesulfonate, brompheniramine maleate, and homatropine methylbromide. The effects of ionic liquid concentrations, salt effect, cations, and anions of ionic liquids on enantioseparation were investigated and the results proved that there was a synergistic effect between hydroxypropyl-β-cyclodextrin and the ionic liquid, and the cationic part of the ionic liquid played an important role in the increased resolution. With the developed dual system, all the enantiomers of 10 analytes were well separated in resolutions of 5.35, 1.76, 1.85, 2.48, 2.88, 1.43, 5.45, 4.35, 2.76, and 2.98, respectively. In addition, the proposed method was applied to the determination of the enantiomeric purity of S-ofloxacin after validation of the method in terms of selectivity, repeatability, linearity range, accuracy, precision, limit of detection (LOD), and limit of quality (LOQ). Chirality 25:409-414, 2013.