188112-24-5

Basic information

• Product Name: trifluoro-methanesulfonic acid 4-diisopropylcarbamoyl-phenyl ester
• CAS NO: 188112-24-5
• Molecular Weight: 353.362
• Mol File: 188112-24-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: trifluoro-methanesulfonic acid 4-diisopropylcarbamoyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: trifluoro-methanesulfonic acid 4-diisopropylcarbamoyl-phenyl ester(188112-24-5)
• EPA Substance Registry System: trifluoro-methanesulfonic acid 4-diisopropylcarbamoyl-phenyl ester(188112-24-5)

Safety Data

• Hazardous Substances Data: 188112-24-5(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 79119-46-3 4-hydroxy-N,N-bis(1-methylethyl)benzamide 
• 28141-24-4 4-hydroxybenzoyl chloride 
• 99-96-7 4-hydroxy-benzoic acid 

Relevant articles and documents

Biphenyls as surrogates of the steroidal backbone. Part 2: Discovery of a novel family of non-steroidal 5-α-reductase inhibitors

A new family of non-steroidal 5-α-reductase inhibitors was designed by replacing the steroid skeleton of an inhibitor related to estrone by a biphenyl moiety. This hypothesis originated from the reported estrogenic activity of a few biphenyl compounds (see Part 1 of this paper; Lesuisse et al. Bioorg. Med. Chem. Lett. 2001, 11, 1709). Two compounds turned out to be potent type 2 5-α-reductase inhibitors with IC50's of inhibition in the nanomolar range. These are to our knowledge amongst the most potent non-steroidal 5-α-reductase inhibitors described to date.