18818-43-4

Basic information

• Product Name: 2-(naphthalen-2-yl)quinazolin-4(3Η)-one
• Synonyms: 2-(naphthalen-2-yl)quinazolin-4(3Η)-one
• CAS NO: 18818-43-4
• Molecular Weight: 272.306
• Mol File: 18818-43-4.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 2-(naphthalen-2-yl)quinazolin-4(3Η)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(naphthalen-2-yl)quinazolin-4(3Η)-one(18818-43-4)
• EPA Substance Registry System: 2-(naphthalen-2-yl)quinazolin-4(3Η)-one(18818-43-4)

Safety Data

• Hazardous Substances Data: 18818-43-4(Hazardous Substances Data)

Upstream product

• 1592-38-7 2-Naphthalenemethanol 
• 28144-70-9 anthranilic acid amide 
• 93-09-4 naphthalene-2-carboxylate 
• 2018-90-8 naphthalen-2-ylmethylamine 
• 2506-41-4 1-chloromethylnaphthalene 
• 581-96-4 2-naphthylacetic acid 
• 580-13-2 2-bromonaphthalene 
• 201230-82-2 carbon monoxide 
• 1452311-08-8 (Z)-N-benzyl-N′-hydroxy-2-naphthimidamide 
• 65788-68-3 N-hydroxy-2-naphthalenecarboximidoyl chloride 
• 51873-98-4 2-naphthaldoxime 
• 66-99-9 β-naphthaldehyde 

Relevant articles and documents

Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation

The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as ?F, ?Cl, ?Br, ?CF3, ?OMe, ?NO2, and alkyl, etc.

Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst

Herein, we report a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and anin situgenerated non-native secondary amine. The catalyst consists of ano-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.

Palladium(II) N^O Chelating Complexes Catalyzed One-Pot Approach for Synthesis of Quinazolin-4(3 H)-ones via Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and 2-Aminobenzamide

A convenient protocol for the one-pot synthesis of quinazolin-4(3H)-ones using palladium(II) complexes via dehydrogenative coupling of readily available benzyl alcohols and 2-aminobenzamide has been described. New structurally related Pd(II) N^O chelating complexes of general configuration [Pd(L)Cl(PPh3)] (where L = dimethylamino benzoylhydrazone ligands) have been designed and synthesized. The formation of the complexes has been recognized by analytical and spectral methods (FT-IR, NMR, HR-MS). The presence of a square-planar geometry around the palladium(II) ion was confirmed by single crystal X-ray diffraction study. A wide range of substituted quinazolinones have been successfully achieved from a diverse range of benzyl alcohols in good to excellent yields using 1.0 mol % of catalyst loading under aerobic conditions. Furthermore, control experiments reveal that the dehydrogenative coupling reaction involves initially the formation of an aldehyde intermediate and subsequent formation of a cyclic aminal intermediate.