18818-45-6Relevant academic research and scientific papers
Metal-free sequential dual oxidative amination of C(sp3)–H bonds: A direct approach to benzothiadiazine 1,1-dioxide derivatives
Wang, Dongyin,Li, Xiaokang,Zhao, Yongli,Chen, Junmin
, p. 351 - 356 (2017/02/10)
An efficient and metal-free Di-tert-butyl peroxide (DTBP)-promoted dual oxidative amination annulation of 2-amino arylsulfonamide with methylarene has been developed. This protocol provides straightforward access to benzothiadiazine 1,1-dioxide derivatives without using prefunctionalized substrates in good to excellent yields with good functional group tolerance.
Oxidative synthesis of quinazolinones and benzothiadiazine 1,1-dioxides from 2-aminobenzamide and 2-aminobenzenesulfonamide with benzyl alcohols and aldehydes
Sharif, Muhammad,Opalach, Julita,Langer, Peter,Beller, Matthias,Wu, Xiao-Feng
, p. 8 - 17 (2014/01/06)
An interesting procedure for the zinc-catalyzed oxidative transformation of ready available 2-aminobenzamide, 2-aminobenzenesulfonamide with benzyl alcohols has been developed. Various quinazolinones and benzothiadiazine 1,1-dioxides were prepared in moderate to good yields under identical conditions. The reactions of both aromatic aldehydes and aliphatic aldehydes with 2-aminobenzamide under catalyst free conditions were described as well. In water media, the products were formed in good yields.
Ruthenium-catalysed oxidative synthesis of heterocycles from alcohols
Watson, Andrew J. A.,Maxwell, Aoife C.,Williams, Jonathan M. J.
supporting information; experimental part, p. 240 - 243 (2012/01/13)
Ruthenium-catalysed hydrogen transfer has been successfully used for the conversion of alcohols into either 2,3-dihydroquinazolines or quinazolines. The choice of reaction conditions allows for the selective formation of either heterocycle and the methodology can also be applied to the sulfonamide analogue.
Facile synthesis of 2H-1,2,4-benzothiadiazine 1,1-dioxides promoted by Sml2
Su, Weike,Cai, Hongfei,Yang, Bibo
, p. 87 - 88 (2007/10/03)
2H-1,2,4-Benzothiadiazine 1,1-dioxides are prepared in good yields via reductive cyclisation of N,N-diethyl-o-nitrobenzenesulfonamides with appropriate nitriles promoted by Sml2 under mild and neutral conditions.
