188200-05-7

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-
• Synonyms: 1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-;(S)-1-tert-Butyl 2-methyl 5-hydroxypyrrolidine-1,2-dicarboxylate;(2S)-1-tert-Butyl 2-methyl 5-hydroxypyrrolidine-1,2-dicarboxylate
• CAS NO: 188200-05-7
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.27226
• Mol File: 188200-05-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-(188200-05-7)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-(188200-05-7)

Safety Data

• Hazardous Substances Data: 188200-05-7(Hazardous Substances Data)

Usage

General Description

1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)- is a chemical compound that belongs to the category of pyrrolidine carboxylic acid derivatives. It is an ester form of 5-hydroxy-1,2-pyrrolidinedicarboxylic acid, which is a neurotransmitter that plays a role in the brain's reward system. The compound is composed of a pyrrolidine ring with a carboxylic acid group, a hydroxyl group, and a methyl ester functional group. It is commonly used in pharmaceutical research for its potential therapeutic effects on neurological disorders and substance abuse. This chemical compound is also known for its role in modulating excitatory neurotransmission in the brain.

Upstream product

• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 

Downstream Products

• 478239-47-3 methyl (2S)-cis-(Z)-1-(tert-butyloxycarbonyl)-5-[2'-bromo-(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 478239-48-4 methyl (2S)-trans-(Z)-1-(tert-butyloxycarbonyl)-5-[2'-bromo-(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 478239-49-5 methyl (2S)-cis-(Z)-1-(tert-butyloxycarbonyl)-5-[2'-phenyl-(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 478239-50-8 methyl (2S)-cis-(Z)-1-(tert-butyloxycarbonyl)-5-[2'-(4-methoxy-phenyl)-(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 478239-51-9 (6R,9S)-1-aza-3-N-benzoxycarbonylamino-9-methoxycarbonyl-4-phenyl-oxobicyclo[4.3.0]non-3-ene 
• 478239-46-2 methyl (2S)-cis/trans-(Z)-1-(tert-butyloxycarbonyl)-5-[(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 
• 1071993-04-8 C₁₆H₂₅N₃O₅ 
• 1071992-57-8 N1-[(5S,8S,10aR)-8-[N-(1,1-diphenylmethyl)carbamoyl]-3-(3-methylbutyryl)-6-oxoperhydropyrrolo[1,2-a][1,5]diazocin-5-yl]-N²-methyl-L-alaninamide hydrochloride 
• 957135-12-5 methyl (5S,8S,10aR)-5-[(tert-butoxycarbonyl)amino]-6-oxo-decahydro-1H-pyrrolo[1,2-a][1,5]diazocine-8-carboxylate 
• 1419391-16-4 2-bromo-1-(4-bromophenyl)ethanone 
• 1613083-77-4 C₅₀H₅₈N₈O₆ 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 

Relevant articles and documents

Oxidation of α-amino acids promoted by the phthalimide N-oxyl radical: A kinetic and product study

A kinetic study of the hydrogen atom transfer (HAT) reaction from a series of N-Boc- or N-Acetyl-protected amino acids to the phthalimide N-oxyl radical (PINO) was carried out to obtain information about reactivity and selectivity patterns. With amino acids containing aliphatic side chains, the 2nd order rate constants are of the same order of magnitude, in agreement with a HAT process involving the Cα?H bond. Proline is the most reactive substrate suggesting that HAT process involves the Cδ?H bond instead of Cα?H bond. These results are confirmed by the product analysis of the aerobic oxidations of the corresponding N-Boc and N-Ac protected amino acids methyl esters promoted by N-hydroxyphthalimide. Comparison of our results with those reported for HAT reactions to other radical species indicates that PINO displays electrophilic characteristics that are intermediate between those observed for the more stable Br[rad] radical and the more reactive cumyloxyl radical.