188200-05-7

Usage

Uses

Used in Pharmaceutical Research:
1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)is used as a research compound for its potential therapeutic effects on neurological disorders and substance abuse. Its involvement in the brain's reward system and modulation of excitatory neurotransmission make it a promising candidate for the development of treatments for these conditions.
Used in Neurotransmission Modulation:
In the field of neuroscience, 1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)is utilized for its ability to modulate excitatory neurotransmission in the brain. This property is crucial for understanding and potentially treating neurological disorders that involve imbalances in neurotransmitter activity.

Upstream product

• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 

Downstream Products

• 195964-65-9 (2S)-5-allyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 478239-47-3 methyl (2S)-cis-(Z)-1-(tert-butyloxycarbonyl)-5-[2'-bromo-(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 478239-48-4 methyl (2S)-trans-(Z)-1-(tert-butyloxycarbonyl)-5-[2'-bromo-(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 478239-49-5 methyl (2S)-cis-(Z)-1-(tert-butyloxycarbonyl)-5-[2'-phenyl-(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 478239-50-8 methyl (2S)-cis-(Z)-1-(tert-butyloxycarbonyl)-5-[2'-(4-methoxy-phenyl)-(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 478239-51-9 (6R,9S)-1-aza-3-N-benzoxycarbonylamino-9-methoxycarbonyl-4-phenyl-oxobicyclo[4.3.0]non-3-ene 
• 478239-46-2 methyl (2S)-cis/trans-(Z)-1-(tert-butyloxycarbonyl)-5-[(3'-amino-(N-benzyloxycarbonyl)-3'-methoxycarbonyl)-2'-propenyl] prolinate 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 
• 163513-98-2 (-)-(1R,4S)-tert-butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate 
• 211426-31-2 (1R,4S)-2-[1-Phenyl-meth-(Z)-ylidene]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester 
• 211426-29-8 (S)-2-Methoxy-5-(3-phenyl-prop-2-ynyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 211426-27-6 (S)-2-(1-Hydroxy-3-phenyl-prop-2-ynyl)-5-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 211426-30-1 (S)-2-(3-Phenyl-prop-2-ynyl)-5-phenylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 211426-28-7 (S)-2-[1-(Imidazole-1-carbothioyloxy)-3-phenyl-prop-2-ynyl]-5-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Oxidation of α-amino acids promoted by the phthalimide N-oxyl radical: A kinetic and product study

A kinetic study of the hydrogen atom transfer (HAT) reaction from a series of N-Boc- or N-Acetyl-protected amino acids to the phthalimide N-oxyl radical (PINO) was carried out to obtain information about reactivity and selectivity patterns. With amino acids containing aliphatic side chains, the 2nd order rate constants are of the same order of magnitude, in agreement with a HAT process involving the Cα?H bond. Proline is the most reactive substrate suggesting that HAT process involves the Cδ?H bond instead of Cα?H bond. These results are confirmed by the product analysis of the aerobic oxidations of the corresponding N-Boc and N-Ac protected amino acids methyl esters promoted by N-hydroxyphthalimide. Comparison of our results with those reported for HAT reactions to other radical species indicates that PINO displays electrophilic characteristics that are intermediate between those observed for the more stable Br[rad] radical and the more reactive cumyloxyl radical.

Oxidation of L-Proline Methyl Ester Derivatives with the Iodosylbenzene/Trimethylsilylazide Reagent Combination

Oxidation of a series of L-Proline derivatives with the (PhIO)n/TMSN3 reagent combination is reported.Subsequent utilization of the 5-azido N-acyl functionality as a N-acyl iminium ion precursor is described.