188240-69-9Relevant academic research and scientific papers
Replacement of the 1',4'-phenylene region in 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF) by 4,5,6,7-tetrahydrobenzo[c]thiophene and 4,5,6,7-tetrahydroisobenzofuran nuclei
Taylor,Dowling
, p. 1599 - 1603 (1997)
Two new analogs of DDATHF, in which the 1',4'-phenylene unit is replaced by 4,5,6,7-tetrahydrobenzo[c]thiophene and 4,5,6,7-tetrahydroisobenzofuran nuclei, have been prepared and evaluated for in vitro cytotoxicity, GARFT inhibition, and FPGS affinity as potential antitumor agents.
