188244-34-0Relevant academic research and scientific papers
5-Aminopyrazoles from enolisable ketones and 1-cyano-1-alkylhydrazines
Ryckmans, Thomas,Viehe, Heinz-Gunter,Feneau-Dupont, Janine,Tinant, Bernard,Declercq, Jean-Paul
, p. 1729 - 1734 (1997)
The reaction of enolisable ketones with 1-alkyl-1-cyanohydrazines leads to the corresponding cyanohydrazones. These compounds cyclise under thermal or mildly basic conditions, furnishing the corresponding 5-aminopyrazoles in good yield. In some cases, the hydrazones cannot be isolated, and the pyrazole derivatives are directly obtained. Hydrazone-enehydrazine tautomerism was observed, but no subsequent [3,3] rearrangement.
Acyclic cyanamide-based inhibitors of cathepsin K
Barrett, David G.,Deaton, David N.,Hassell, Anne M.,McFadyen, Robert B.,Miller, Aaron B.,Miller, Larry R.,Payne, J. Alan,Shewchuk, Lisa M.,Willard Jr., Derril H.,Wright, Lois L.
, p. 3039 - 3043 (2007/10/03)
Conversion of the proline-derived cyanamide lead to an acyclic cyanamide capable of forming an additional hydrogen bond with cathepsin K resulted in a large increase in inhibitory activity. An X-ray structure of a co-crystal of a cyanamide with cathepsin K confirmed the enzyme interaction. Furthermore, a representative acyclic cyanamide inhibitor 6r was able to attenuate bone resorption in the rat calvarial model.
