188244-51-1

Basic information

• Product Name: 6-amino-1-(2-methoxy-4-methoxycarbonylbenzyl)-4-oxo-1,4-dihydroquinoline
• Synonyms: 6-amino-1-(2-methoxy-4-methoxycarbonylbenzyl)-4-oxo-1,4-dihydroquinoline
• CAS NO: 188244-51-1
• Molecular Weight: 338.363
• Mol File: 188244-51-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-amino-1-(2-methoxy-4-methoxycarbonylbenzyl)-4-oxo-1,4-dihydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-1-(2-methoxy-4-methoxycarbonylbenzyl)-4-oxo-1,4-dihydroquinoline(188244-51-1)
• EPA Substance Registry System: 6-amino-1-(2-methoxy-4-methoxycarbonylbenzyl)-4-oxo-1,4-dihydroquinoline(188244-51-1)

Safety Data

• Hazardous Substances Data: 188244-51-1(Hazardous Substances Data)

Upstream product

• 188244-50-0 1-(2-methoxy-4-methoxycarbonylbenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline 
• 21873-49-4 6-nitroquinoline-4(1H)-one 
• 3556-83-0 methyl 4-methyl-3-methoxybenzoate 
• 70264-94-7 methyl 4-(bromomethyl)-3-methoxybenzoate 
• 100-01-6 4-nitro-aniline 
• 25063-45-0 2,2-dimethyl-5-(((4-nitrophenyl)amino)methylene)-1,3-dioxane-4,6-dione 

Downstream Products

• 188244-53-3 4-[6-(2-Cyclopentyl-acetylamino)-4-oxo-4H-quinolin-1-ylmethyl]-3-methoxy-benzoic acid 
• 188244-52-2 4-[6-(2-Cyclopentyl-acetylamino)-4-oxo-4H-quinolin-1-ylmethyl]-3-methoxy-benzoic acid methyl ester 

Relevant articles and documents

Synthesis and pharmacological evaluation of new cysLT1 receptor antagonists

This paper describes the synthesis and pharmacological evaluation of three series of compounds 4a-b, 13a-k and 19, structurally related to the known potent cysLT1 receptor antagonists RG-12553, IC1-204219 and ONO-1078, respectively. The common structural feature of these new series is the presence of a 4-quinolone nucleus acting as a template for substitution of the aromatic nucleus present in the prototype antagonists. We describe the evolution of these series leading to antagonists with potency at nanomolar concentrations in vitro.