188251-66-3Relevant articles and documents
New chiral inhibitors of induced platelet aggregation: The enantiomeric specificity of (R)- and (S)-methyl and ethyl esters of 1-{4-[(1-hydroxycarbonyl)-ethoxy]-benzyl}-1H-1,2,3-triazole as a tool for determining their biological target
Biagi,Giorgi,Livi,Scartoni,Catalani,Gervasi
, p. 761 - 766 (2007/10/03)
The synthesis of title enantiomers was accomplished and their biological behaviour as inhibitors of rabbit platelet aggregation process induced by ADP and arachidonic acid was determined. Structure-activity comparison with that of SM-12502 [(2R,5S)-(+)3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride] and Dazoxiben {4-[2-(1H-imidazol-1-yl)-ethoxy]-benzoic acid} allowed us to formulate the possible capability for the synthesized compounds to interact with the biological targets of the model molecules.