188254-34-4

Upstream product

• 71240-67-0 3,4-di-O-allyl-D-mannitol 
• 188254-37-7 3,4-di-O-Allyl-1.6-di-O-tert-butyldimethylsilyl-D-mannitol 
• 58315-80-3 3,4-di-O-allyl-1,2:5,6-di-O-isopropylidene-D-mannitol 
• 178909-09-6 3,4-di-O-allyl-1,2:5,6-dianhydro-L-iditol 
• 178909-08-5 3,4-di-O-allyl-1,6-di-O-tert-butyldimethylsilyl-2,5-di-O-methanesulfonyl-D-mannitol 

Downstream Products

• 188254-35-5 (3S,4S,5S,6S)-3,6-Bis-(3,5-difluoro-benzyloxy)-1-methyl-azepane-4,5-diol 

Relevant academic research and scientific papers

Hydroxyazepanes as inhibitors of glycosidase and HIV protease

Hydroxyazepanes display inhibitory activity with respect to glycosidase, with Kivalues from-moderate to low micromolar range. Benzyl and 3,6-dibenzyl derivatives of hydroxyazepanes display inhibitory activity with respect to HIV protease. These compounds are synthesized either by chemoenzymatic or chemical methodologies.

C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases.

C2-Symmetrical tetrahydroxyazepanes were synthesized as inhibitors for glycosidases. Tetrahydroxyazepane 1 is a non-specific inhibitor of various glycosidases, while compounds 2, 3 and 4 specifically inhibit beta-N-acetylglucosaminidase, beta-glucosidase, and alpha-fucosidase, respectively, with Ki in the micromolar range. Compound 1 is not an inhibitor of HIV/FIV proteases, but its 3,6-difluorobenzyl derivatives are moderate inhibitors of both enzymes.