188290-89-3

Upstream product

• 23138-64-9 3-acetylphenyl isocyanate 
• 188290-83-7 3-Amino-1-[2-(3-aza-bicyclo[3.2.2]non-3-yl)-2-oxo-ethyl]-5-(2-fluoro-phenyl)-9-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 188290-74-6 2-Bromo-N-[2-(2-fluoro-benzoyl)-6-methyl-phenyl]-acetamide 
• 188290-73-5 (2-amino-3-methylphenyl)-(2-fluorophenyl)methanone 
• 95-53-4 o-toluidine 
• 394-47-8 2-fluorobenzonitrile 
• 188290-82-6 [1-[2-(3-Aza-bicyclo[3.2.2]non-3-yl)-2-oxo-ethyl]-5-(2-fluoro-phenyl)-9-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester 
• 188290-80-4 [3-tert-Butoxycarbonylamino-5-(2-fluoro-phenyl)-9-methyl-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester 
• 188290-81-5 [3-tert-Butoxycarbonylamino-5-(2-fluoro-phenyl)-9-methyl-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid 
• 188290-77-9 2-[5-(2-Fluoro-phenyl)-9-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-isoindole-1,3-dione 
• 188290-79-1 [5-(2-Fluoro-phenyl)-9-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester 
• 188290-76-8 Acetic acid 5-(2-fluoro-phenyl)-9-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl ester 
• 188290-78-0 3-Amino-5-(2-fluoro-phenyl)-9-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 188290-75-7 5-(2-Fluoro-phenyl)-9-methyl-4-oxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one 

Relevant academic research and scientific papers

1,4-benzodiazepinones and their uses as CCK antagonists

Benzodiazepine derivatives of the formula: wherein R2is alkyl or cycloalkyl-alkyl when R4is hydrogen, or R2is a variety of specified groups when R4is alkyl, halogen or dialkylamino, are useful as cholecystokinin

Dual CCK-A and -B receptor antagonists (I). C9-Methyl-1,4-benzodiazepines

A novel series of potent CCK-A and CCK-B dual antagonists has been prepared which incorporate a methyl substituent at the 9 position of a 1,4-benzodiazepine ring system. FR193108 ((+)-11) was selected for further biological evaluation, and is expected to be more efficacious than CCK-A selective antagonists for the treatment of pancreatitis, since it has high and well-balanced affinities for both CCK-A and -B receptors.