188302-43-4Relevant academic research and scientific papers
Asymmetric Synthesis of Six-Membered Cyclic Sulfamides via Palladium-Catalyzed Alkene Carboamination Reactions
Garlets, Zachary J.,Wolfe, John P.
, p. 4444 - 4452 (2018/05/28)
The asymmetric synthesis of six-membered cyclic sulfamides via palladium-catalyzed alkene carboamination reactions of N -homoallylsulfamides with aryl halides is described. High levels of enantioselectivity were obtained with a catalyst composed of Pd 2 dba 3 and (S)-Siphos-PE.
NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND
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Paragraph 0351-0353, (2016/08/29)
The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].
N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES
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Page/Page column 173-174, (2012/08/08)
The present invention provides a compound of general formula:wherein Z2-Z6 include one or two nitrogen atoms as described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I and isomers thereof, and pharmaceutical compositions comprising such compounds.
N-ACYL PYRIMIDINE BIARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS
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Page/Page column 216, (2012/08/08)
The present invention provides a compound of the general formula (1): wherein one of X and Y is N and the other is an optionally substituted carbon atom, and Z2-Z5 represent one or two nitrogen atoms, as further described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals and as components of pharmaceutical compositions. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds described herein or pharmaceutical compositions comprising such compounds.
PYRAZINYLPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES
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Page/Page column 100, (2011/04/14)
The present invention provides a compound of Formula (I) and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor.
HETEROARYL COMPOUNDS AS KINASE INHIBITORS
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Page/Page column 100, (2011/04/14)
The present invention provides a compound of Formula (I): and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor
Copper-catalyzed allylation of carbonyl derivatives using allyl(2-pyridyl)silanes
Kamei, Toshiyuki,Fujita, Kazuyoshi,Itami, Kenichiro,Yoshida, Jun-Ichi
, p. 4725 - 4728 (2007/10/03)
(Chemical Equation Presented) We have developed an efficient copper-catalyzed allylation of carbonyl derivatives using allyl(2-pyridyl) silanes, in which the strong directing effect of the 2-pyridyl group was observed. A useful synthesis and allylation of
Synthesis of azetidine and pyrrolidine derivatives through selenium-induced cyclization of secondary homoallylamines - A 77Se NMR study
Pannecoucke, Xavier,Outurquin, Francis,Paulmier, Claude
, p. 995 - 1006 (2007/10/03)
Treatment of α-alkyl and α,α-dialkyl homoallylic amines 1 with PhSeX (X = C1, Br, I), in CH3CN containing sodium carbonate produced mixtures of azetidines 2 and pyrrolidines 3. The cyclization also occurred in the absence of Na2CO3, and the corresponding azetidinium and pyrrolidinium salts 2(HX) and 3(HX) were formed in CDCl3 or CH3CN. The crude reaction mixtures were analysed by 77Se NMR. Each product - 2, 3, 2(HX), and 3(HX) - was characterized by its 77Se chemical shift, and the product ratios were determined for each reaction. The ratios of azetidine 2 to pyrrolidine 3 increased not only according to the steric hindrance around the α-carbon, but also with the nature of the counterion X- (PhSeCl 1, R2 ≠H), produced only the azetidinium salts 2(HI), allowing the isolation of the corresponding azetidines 2, albeit in poor yield. Some reactions were monitored by 77Se NMR at the beginning of the addition-cyclization process. No intermediates were observed when PhSeI was used, but the thermodynamic addition products 5(Br), 5(HBr), and some dibromoselenuranes 8 were detected. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
Synthesis of azetidines by electrophilic selenium-induced cyclization of homoallylic benzylamines
Berthe, Benedicte,Outurquin, Francis,Paulmierz.ast, Claude
, p. 1393 - 1396 (2007/10/03)
Homoallyl benzylamines prepared by allylation of the corresponding N-benzylimines, have been subjected to a selenium-induced cyclization under various conditions. At room temperature. the 4-exo and the 5-endo modes are competitive. In acetonitrile, the azetidine has been isolated as the major cyclization product, especially for homoallylamines derived from ketimines. With an excess or selenium reagent, 3-halopyrrolidines have been obtained.
