188302-58-1Relevant academic research and scientific papers
Synthesis of azetidines by electrophilic selenium-induced cyclization of homoallylic benzylamines
Berthe, Benedicte,Outurquin, Francis,Paulmierz.ast, Claude
, p. 1393 - 1396 (2007/10/03)
Homoallyl benzylamines prepared by allylation of the corresponding N-benzylimines, have been subjected to a selenium-induced cyclization under various conditions. At room temperature. the 4-exo and the 5-endo modes are competitive. In acetonitrile, the azetidine has been isolated as the major cyclization product, especially for homoallylamines derived from ketimines. With an excess or selenium reagent, 3-halopyrrolidines have been obtained.
