188343-77-3 Usage
General Description
MBP146-78 is a potent and selective small molecule inhibitor of the protein methionine aminopeptidase-2 (MetAP2). It has been shown to effectively inhibit the growth of certain cancer cells in preclinical studies. MBP146-78 has also demonstrated the potential to inhibit tumor angiogenesis, a critical process for tumor growth and metastasis. Additionally, MBP146-78 has been identified as a potential therapeutic for neurodegenerative diseases, such as Alzheimer's disease, due to its ability to reduce the accumulation of amyloid-beta peptides in the brain. Overall, MBP146-78 shows promise as a potential treatment for cancer and neurodegenerative diseases, making it a valuable chemical compound for further medical research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 188343-77-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,3,4 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 188343-77:
(8*1)+(7*8)+(6*8)+(5*3)+(4*4)+(3*3)+(2*7)+(1*7)=173
173 % 10 = 3
So 188343-77-3 is a valid CAS Registry Number.
188343-77-3Relevant articles and documents
THERAPEUTIC METHODS AND COMPOUNDS
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, (2020/11/03)
The invention provides a compound of formula I: (I) or a pharmaceutically acceptable salt thereof, wherein R1-R5 Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful to treat malaria.
2-substituted aryl pyrroles, compositions containing such compounds and methods of use
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, (2008/06/13)
The present invention addresses 2-substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production or activity o
