188345-76-8

Basic information

• Product Name: 2,4-Pyrrolidinedicarboxylicacid,cis-(9CI)
• Synonyms: 2,4-Pyrrolidinedicarboxylicacid,cis-(9CI);NRSBQSJHFYZIPH-IMJSIDKUSA-N
• CAS NO: 188345-76-8
• Molecular Formula: C6H9NO4
• Molecular Weight: 159.14
• Product Categories: CARBOXYLICACID;PYRROLE
• Mol File: 188345-76-8.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Pyrrolidinedicarboxylicacid,cis-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pyrrolidinedicarboxylicacid,cis-(9CI)(188345-76-8)
• EPA Substance Registry System: 2,4-Pyrrolidinedicarboxylicacid,cis-(9CI)(188345-76-8)

Safety Data

• Hazardous Substances Data: 188345-76-8(Hazardous Substances Data)

Usage

Synonym

cis-2,4-Pyrrolidinedicarboxylic acid

Chemical structure

a pyrrolidine derivative with a cis-configuration

Occurrence in the human body

not found naturally

Primary uses

research and pharmaceutical applications

Importance

intermediate in the synthesis of various pharmaceuticals and organic compounds

Potential applications

treatment of neurological disorders, such as Alzheimer's disease, due to its ability to act as an agonist at certain glutamate receptors in the brain

Additional information

further research is needed to fully understand its pharmacological properties and potential therapeutic uses.

Upstream product

• 64750-03-4 (2S,4R)-4-methoxycarbonylproline methyl ester 
• 130830-61-4 N-(benzyloxycarbonyl)-cis-4-(tosyloxy)-L-proline ethyl ester 
• 64187-47-9 1-benzyloxycarbonyl-4-keto-L-proline 
• 130830-63-6 N-(benzyloxycarbonyl)-cis-4-(tosyloxy)-D-proline ethyl ester 
• 130830-62-5 N-(benzyloxycarbonyl)-trans-4-(tosyloxy)-D-proline ethyl ester 
• 130830-60-3 1-benzyl 2-ethyl(2S,4R)-4-[[(4-methylbenzene)sulfonyl]oxy]pyrrolidine-1,2-dicarboxylate 
• 64-19-7 acetic acid 
• 130830-73-8 N-(benzyloxycarbonyl)-cis-4-carboxy-L-proline 
• 130830-74-9 N-(benzyloxycarbonyl)-trans-4-carboxy-L-proline 
• 130830-76-1 N-(benzyloxycarbonyl)-cis-4-carboxy-D-proline 
• 130830-75-0 N-(benzyloxycarbonyl)-trans-4-carboxy-D-proline 
• 212266-69-8 (S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol 
• 212266-71-2 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-(S)-1-oxiranylmethyl-amine 
• 220047-66-5 ((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol 

Relevant articles and documents

Selenium-containing photosensitizer as well as preparation method and application thereof

The invention discloses a selenium-containing photosensitizer as well as a preparation method and application thereof. A novel selenium-containing photosensitizer with an anti-tumor angiogenesis effect is synthesized for a first time. The selenium-containing photosensitizer can be applied to treatment on skin scale cancer and is remarkable in effect, the dosage of the selenium-containing photosensitizer is far lower than that of 5-ALA in the market, in addition is free of antibiotics, free of drug resistance and small in side effect, and is safe and non-toxic and economic and practical; in addition, because of the limited light penetration function and other factors, a tumor treatment effect can be achieved even for tumor tissue without light dynamic response through tumor angiogenesis inhibition.

An enantioselective route to pyrrolidines: Removal of the chiral template from homochiral pyrroloimidazoles

Two-step reductive removal of the chiral template from optically active pyrroloimidazoles, available from 1,3-dipolar cycloaddition of homochiral 4,5-dihydroimidazolium ylides, gives optically active substituted pyrrolidines. Selective manipulation of the substituents affords, e.g., naturally occurring and other optically active proline derivatives, and optically active pyrrolizidines and indolizidines.

Asymmetric synthesis of 4-substituted prolines as conformationally constrained amino acid analogues

Treatment of readily available chiral building block 1 with (2R)-2,3-O- isopropylideneglyceraldehyde (5) provides a new route for asymmetric synthesis of 2,4-disubstituted pyrrolidines. Several proline-amino acid chimeras: proline-leucine, proline-lysine, proline-arginine and proline- glutamic acid, are synthesized in highly diastereomerically pure forms.