188359-34-4

Upstream product

• 423772-15-0 (2E,4E,14E,20E)-(7R,8R,9R,10R,13S,17R,19R,23S,24R,25S,26S)-9-(tert-Butyl-dimethyl-silanyloxy)-13,19-dimethoxy-8,10,17,24,26-pentamethyl-7-methylsulfanylmethoxy-23,25-bis-triethylsilanyloxy-27-trityloxy-heptacosa-2,4,14,20-tetraenoic acid ethyl ester 
• 423772-12-7 2,2-Dimethyl-propionic acid (10E,16E)-(3R,4R,5R,6R,9S,13R,15R,19S,20R,21S,22S)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13,20,22-pentamethyl-3-methylsulfanylmethoxy-19,21-bis-triethylsilanyloxy-23-trityloxy-tricosa-10,16-dienyl ester 
• 423772-13-8 (10E,16E)-(3R,4R,5R,6R,9S,13R,15R,19S,20R,21S,22S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13,20,22-pentamethyl-3-methylsulfanylmethoxy-19,21-bis-triethylsilanyloxy-23-trityloxy-tricosa-10,16-dien-1-ol 
• 423772-14-9 (10E,16E)-(3R,4R,5R,6R,9S,13R,15R,19S,20R,21S,22S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13,20,22-pentamethyl-3-methylsulfanylmethoxy-19,21-bis-triethylsilanyloxy-23-trityloxy-tricosa-10,16-dienal 
• 423771-75-9 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester 
• 423771-77-1 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-methylsulfanylmethoxy-16-trityloxy-hexadec-10-enyl ester 
• 423771-76-0 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-9,15-dimethoxy-4,6,13-trimethyl-16-trityloxy-hexadec-10-enyl ester 
• 423771-78-2 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-16-hydroxy-9,15-dimethoxy-4,6,13-trimethyl-3-methylsulfanylmethoxy-hexadec-10-enyl ester 
• 423772-09-2 (2S,3S,4R,5S)-2,4-Dimethyl-7-phenylsulfanyl-1-trityloxy-heptane-3,5-diol 
• 423772-07-0 (2S,3S,4R,5S)-2,4-Dimethyl-7-phenylsulfanyl-1-triisopropylsilanyloxy-heptane-3,5-diol 
• 423772-06-9 (3S,4R,5S,6S)-4,6-Dimethyl-7-triisopropylsilanyloxy-heptane-1,3,5-triol 
• 423772-08-1 (2S,3S,4R,5S)-2,4-Dimethyl-7-phenylsulfanyl-heptane-1,3,5-triol 
• 188359-29-7 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-methylsulfanylmethoxy-16-oxo-hexadec-10-enyl ester 
• 10236-14-3 4-(diethoxyphosphoryl)-but-2-enoic acid ethyl ester 

Downstream Products

• 188405-25-6 C₇₁H₁₁₁NO₁₀Si₂ 
• 423772-16-1 (3E,5E,15E,21E)-(8R,9R,10R,11R,14S,18R,20R,24S)-10-(tert-Butyl-dimethyl-silanyloxy)-24-((1S,2S,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl)-14,20-dimethoxy-9,11,18-trimethyl-8-methylsulfanylmethoxy-oxacyclotetracosa-3,5,15,21-tetraen-2-one 
• 423772-65-0 (3E,5E,15E,21E)-(8R,9R,10R,11R,14S,18R,20R,24S,25R,26S)-10-(tert-Butyl-dimethyl-silanyloxy)-24-hydroxy-14,20-dimethoxy-9,11,18,25-tetramethyl-8-methylsulfanylmethoxy-26-((S)-1-methyl-2-trityloxy-ethyl)-oxacyclohexacosa-3,5,15,21-tetraen-2-one 
• 423772-18-3 (3E,5E,15E,21E)-(8R,9R,10R,11R,14S,18R,20R,24S)-10-(tert-Butyl-dimethyl-silanyloxy)-24-[(1R,2S,3S)-2-(tert-butyl-dimethyl-silanyloxy)-1,3-dimethyl-4-trityloxy-butyl]-8-hydroxy-14,20-dimethoxy-9,11,18-trimethyl-oxacyclotetracosa-3,5,15,21-tetraen-2-one 
• 423772-17-2 10-(tert-butyl-dimethyl-silanyloxy)-24-[2-(tert-butyl-dimethyl-silanyloxy)-1,3-dimethyl-4-trityloxy-butyl]-14,20-dimethoxy-9,11,18-trimethyl-8-methylsulfanylmethoxy-oxacyclotetracosa-3,5,15,21-tetraen-2-one 

Relevant academic research and scientific papers

Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs

Artificial analogs of aplyronine A (1), a potent antitumor macrolide, were synthesized and structure-activity (cytotoxicity and actin-depolymerizing activity) relationships were investigated; the side-chain in 1 was found to play a key role in both biological activities.

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.