188359-34-4Relevant articles and documents
Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs
Kigoshi, Hideo,Suenaga, Kiyotake,Takagi, Masaki,Akao, Atsushi,Kanematsu, Kengo,Kamei, Noriyuki,Okugawa, Youko,Yamada, Kiyoyuki
, p. 1075 - 1102 (2007/10/03)
Artificial analogs of aplyronine A (1), a potent antitumor macrolide, were synthesized and structure-activity (cytotoxicity and actin-depolymerizing activity) relationships were investigated; the side-chain in 1 was found to play a key role in both biological activities.