1883595-39-8

Basic information

• Product Name: (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide
• Synonyms: (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide;((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methyl)(methyl)oxidoazane
• CAS NO: 1883595-39-8
• Molecular Formula: C17H14FN3O3S
• Molecular Weight: 359.37
• Mol File: 1883595-39-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 613.9±65.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: -0.33±0.53(Predicted)
• CAS DataBase Reference: (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide(1883595-39-8)
• EPA Substance Registry System: (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide(1883595-39-8)

Safety Data

• Hazardous Substances Data: 1883595-39-8(Hazardous Substances Data)

Usage

Uses

(Z)-N-((5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine Oxide is an impurity of Vonoprazan a novel potassium-?competitive acid blocker for the treatment of acid-?related diseases.

Upstream product

• 655-15-2 2-bromo-2'-fluoroacetophenone 
• 881674-56-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 881674-06-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 881677-11-8 5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde 
• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 1807642-39-2 5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile 
• 1240948-77-9 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 
• 1240948-72-4 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 
• 312307-38-3 2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile 

Relevant articles and documents

Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate

A first synthetic research concerning four observed metabolites and their deuterium-labeled analogues of reflux esophagitis drug vonoprazan fumarate is reported. Among which the synthetic methods of three metabolites M ? I, M-III, M-IV-Sul, and four stable isotop labeled analogues M-I-d4, M-II-d4, M-III-d4, M-IV-Sul-d4 have not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy.