18837-76-8Relevant academic research and scientific papers
Minimizing Aryloxy Elimination in RhI-Catalyzed Asymmetric Hydrogenation of β-Aryloxyacrylic Acids using a Mixed-Ligand Strategy
Li, Yang,Wang, Zheng,Ding, Kuiling
supporting information, p. 16387 - 16390 (2015/11/09)
The first example of efficient asymmetric hydrogenation of challenging β-aryloxyacrylic acids was realized using a RhI-complex based on the heterocombination of a readily available chiral monodentate secondary phosphine oxide (SPO) and an achiral monodentate phosphine ligand as the catalyst. Excellent enantioselectivities (92->99% ee) were achieved for a wide variety of chiral β-aryloxypropionic acids with minor aryloxy elimination in most cases. The resultant products were readily transformed into biologically active compounds through simple synthetic manipulations.
Enantiopure β-methoxy carboxyl derivatives from a chiral titanium enolate and dimethyl acetals
Cosp, Annabel,Romea, Pedro,Urpí, Fèlix,Vilarrasa, Jaume
, p. 4629 - 4631 (2007/10/03)
Lewis acid-mediated reaction of the titanium enolate arising from (S)-N-acetyl-4-isopropyl-1,3-thiazolidine-2-thione with dimethyl acetals furnishes β-methoxy carboxyl adducts in good yields and stereoselectivities. The adducts can be, in turn, transformed into a wide range of enantiopure α-unsubstituted β-methoxy carboxyl derivatives in excellent yields.
