188404-32-2

Basic information

• Product Name: methyl (S)-N-butoxycarbonyl-4-nitrophenylalaninate
• Synonyms: methyl (S)-N-butoxycarbonyl-4-nitrophenylalaninate
• CAS NO: 188404-32-2
• Molecular Weight: 324.334
• Mol File: 188404-32-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl (S)-N-butoxycarbonyl-4-nitrophenylalaninate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (S)-N-butoxycarbonyl-4-nitrophenylalaninate(188404-32-2)
• EPA Substance Registry System: methyl (S)-N-butoxycarbonyl-4-nitrophenylalaninate(188404-32-2)

Safety Data

• Hazardous Substances Data: 188404-32-2(Hazardous Substances Data)

Upstream product

• 17193-40-7 (S)-4-nitrophenylalanine methyl ester hydrochloride 
• 592-34-7 carbonochloridic acid, butyl ester 

Downstream Products

• 188404-33-3 methyl (S)-N-butoxycarbonyl-4-aminophenylalaninate 

Relevant articles and documents

A process for the purification of (S)-4-((3-(dimethylamino)ethyl)-1H-indol-5yl)-methyl)-2-oxazolidinone

A process for the purification of (S)-4-{[3-(dimethylamino)ethyl]-1H-indol-5yl]-methyl}-2-oxazolidinone and non-solvated, pure (S)-4-{[3-(dimethylamino) ethyl]-1H-indol-5y1]-methyl}-2-oxazolidinone.

One pot synthesis of 2-oxazolidinone derivatives

PCT No. PCT/GB96/01885 Sec. 371 Date May 13, 1998 Sec. 102(e) Date May 13, 1998 PCT Filed Aug. 2, 1996 PCT Pub. No. WO97/06162 PCT Pub. Date Feb. 20, 1997The present invention provides an improved process for preparing (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone which comprises: a) forming a carbamate of formula (III), from methyl 4-nitro-(L)-phenylalaninate hydrochloride; b) reducing the compound of formula (III) to give the compound of formula (IV); c) reducing the methyl ester grouping in the compound of formula (IV) to give the compound of formula (V); d) ring closure of the compound of formula (V) to give the compound of formula (VI); e) diazonium salt formation from the compound of formula (VI) followed by reduction to give the compound of formula (VII); f) Fischer reaction of the compound of formula (VII) to give (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone.