188439-67-0Relevant academic research and scientific papers
Synthesis of 1,4-dihydropyridines by regioselective additions of benzylic zinc bromides to pyridinium salts and their aromatizations to 4-benzylpyridines
Krapcho, A. Paul,Waterhouse, David J.,Hammach, Abdelhakim,Di Domenico, Roberto,Menta, Ernesto,Oliva, Ambrogio,Spinelli, Silvano
, p. 781 - 794 (1997)
Benzylic zinc reagents add with high regioselectivity to 1-(phenoxycarbonyl) salts of methyl nicotinate to yield methyl-1-(phenoxycarbonyl)-4-benzyl-1,4-dihydronicotinates. The dihydronicotinates on heating with sulfur in decalin afford methyl 4-benzylnicotinates.
