188472-58-4Relevant academic research and scientific papers
Total synthesis of milbemycin E: Resolution of the C(1)-C(10) fragment and final assembly
Steel, Patrick G.,Mills, Owen S.,Parmee, Emma R.,Thomas, Eric J.
, p. 391 - 400 (2007/10/03)
The racemic hydroxycyclohexanone (±)-7, prepared by the Robinson addition of the keto ester 5 to 3-methylbut-3-enone 6, has been reduced stereoselectively to give the racemic cyclohexanediol (±)-8. This has been resolved by fractional crystallisation of t
A Total Synthesis of Milbemycin E
Parmee, Emma R.,Steel, Patrick G.,Thomas, Eric J.
, p. 1250 - 1253 (2007/10/02)
Milbemycin E (1) and 3,4-dihydromilbemycin E (34) have been synthesized, the C(1)-C(10) fragment being prepared using a stereoselective Robinson annelation.
