188475-11-8Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS
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, (2009/12/27)
The present invention relates to novel heterocyclic compounds of Formulae I-III: Formula I; [Chemical Formulas should be inserted here as they appears on abstract in.pdf form.] Formula II; Formula III as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.
A simple one-pot preparation of diazoacetoacetate derivatives from aldehydes
Erhunmwunse, Marvis O.,Steel, Patrick G.
experimental part, p. 8675 - 8677 (2009/04/11)
(Chemical Equation Presented) Diazoacetoacetate derivatives can be simply and efficiently prepared from aldehydes in a one-pot process involving initial DBU-promoted "aldol" condensation with ethyl diazoacetate followed by in situ oxidation with IBX. Aryl, alkyl, and unsaturated aldehydes are all viable substrates.
Discovery of novel hydroxy pyrazole based factor IXa inhibitor
Vijaykumar, Dange,Sprengeler, Paul A.,Shaghafi, Michael,Spencer, Jeffrey R.,Katz, Brad A.,Yu, Christine,Rai, Roopa,Young, Wendy B.,Schultz, Brian,Janc, James
, p. 2796 - 2799 (2007/10/03)
Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.
Metal substituted diazo esters as substrates for cross coupling reactions
Padwa, Albert,Sa, Marcus M.,Weingarten, M. David
, p. 2371 - 2386 (2007/10/03)
Ethyl (trialkylstannyl)diazoacetates have been employed as substrates in the Stille reaction, The palladium(O)-catalyzed cross coupling works well with aryl iodides but not with acyl or aryl chlorides. Bis-[ethoxycarbonyl-diazomethyl]-mercury showed high
