188488-61-1

Upstream product

• 79229-99-5 (Z)-N-(4'-methoxyphenyl)methyl-3-amino-3-phenyl acrylate 
• 329319-62-2 C₁₇H₁₇NO₃ 
• 710293-16-6 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 37088-67-8 methyl (3R)-3-amino-3-phenylpropanoate 

Relevant academic research and scientific papers

Asymmetric transfer hydrogenations of β-N-substituted enamino esters with ammonia borane

Optically active β-amino acids and their derivatives are very useful building blocks in synthetic and medicinal chemistry. The catalytic asymmetric reduction of β-enamino esters is one of the most efficient approaches for their synthesis. Ammonia borane w

Solid Supported Chiral N-Picolylimidazolidinones: Recyclable Catalysts for the Enantioselective, Metal- and Hydrogen-Free Reduction of Imines in Batch and in Flow Mode

A new class of solid supported chiral imidazolidinone organocatalysts for the catalytic reduction of imines with trichlorosilane has been developed. Polystyrene proved to be a more effective support than silica in terms of both chemical and stereochemical

Synthesis of a series of novel chiral Lewis base catalysts and their application in promoting asymmetric hydrosilylation of β-enamino esters

A series of novel chiral Lewis base catalysts were synthesized from l-serine and applied in the hydrosilylation of β-enamino esters, in which the optimal one promoted the reactions to afford a wide variety of β-amino esters in good yields with good enantioselectivities. It is noteworthy that several cyclic substrates were hydrosilylated under the optimal conditions to give the cyclic β-amino esters with high yields, good diastereoselectivities as well as good ee values. The Royal Society of Chemistry 2013.

New, readily available organocatalysts for the enantioselective reduction of α-imino- and β-imino esters

Novel metal-free, readily available chiral catalytic systems for the enantioselective reduction of keto imines are reported. Different β-imino esters were reduced by trichlorosilane in the presence of 10 mol% of a chiral Lewis base easily obtained in one

Lithium amide assisted asymmetric Mannich-type reactions of menthyl acetate with PMP-aldimines

Matrix presented. A lithium enolate of menthyl acetate added to PMP-imines, in the presence of an equimolar amount of lithium diisopropylamide, affords the Mannich-type addition products in high stereoselectivity.