188488-78-0Relevant academic research and scientific papers
Highly asymmetric Pummerer-type reaction induced by ethoxy vinyl esters
Shibata, Norio,Matsugi, Masato,Kawano, Noriyuki,Fukui, Seiji,Fujimori, Chino,Gotanda, Kentoku,Murata, Kenji,Kita, Yasuyuki
, p. 303 - 310 (1997)
Ethoxy vinyl esters (EVE:2) were efficient reagents for promoting the asymmetric Pummerer reaction with high enantioselectivity and high yield in contrast to the generally used acid anhydrides. Increasing the electron-donating ability on the R function in
Enzyme-catalyzed asymmetrization of 2,2-disubstituted 1,3-propanediols using 1-ethoxyvinyl esters
Akai, Shuji,Naka, Tadaatsu,Takebe, Yasushi,Kita, Yasuyuki
, p. 4243 - 4246 (2007/10/03)
The lipase-catalyzed asymmetrization of the prochiral 2,2-disubstituted 1,3-propanediols 1, 6, and 9 was studied using various types of 1-ethoxyvinyl esters 2. Among them, the use of the benzoate 2f provided good chemical and optical yields of the products 3, 7, and 10 bearing chiral quaternary carbon centers which are fairly stable against racemization.
