1885-29-6

Basic information

• Product Name: 2-Aminobenzonitrile
• Synonyms: O-AMINOBENZONITRILE;O-CYANOANILINE;2-AMINOBENZONITRILE;2-CYANOANILINE;2-CYANANILINE;AKOS 91125;ANTHRANILIC ACID NITRILE;ANTHRANILONITRILE
• CAS NO: 1885-29-6
• Molecular Formula: C₇H₆N₂
• Molecular Weight: 118.14
• EINECS: 217-549-9
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Nitriles;Nitriles;Chemical Amines;Amines;Aromatics;Pharmaceutical intermdiate
• Mol File: 1885-29-6.mol
• Article Data: 135

Chemical Properties

• Melting Point: 45-48 °C(lit.)
• Boiling Point: 267-268 °C(lit.)
• Flash Point: >230 °F
• Appearance: Yellow to beige-brown/Crystalline Flakes
• Density: 1.11 g/cm3 (50℃)
• Vapor Pressure: 0.00812mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 0.77(at 25℃)
• Water Solubility: INSOLUBLE
• BRN: 907187
• CAS DataBase Reference: 2-Aminobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminobenzonitrile(1885-29-6)
• EPA Substance Registry System: 2-Aminobenzonitrile(1885-29-6)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 20/21/22-36/37/38-43
• Safety Statements: 26-36/37-36
• RIDADR: 3276
• WGK Germany: 2
• RTECS: CB4575000
• TSCA: T
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1885-29-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

2-Aminobenzonitrile is used for induction of nitrilase activity in Arthrobacter and for radioprotective agent.

Preparation

2-Aminobenzamide was dehydrated to 2-aminobenzonitrile without protection of the amino group in the presence of phenylphosphonyl dichloride and pyridine. Other structural isomers (3-aminobenzamide and 4-aminobenzamide) did not give corresponding aminobenzonitriles.In this paper, the dehydration reactions of 2-aminobenzamide (1a) to 2-aminobenzonitrile (3a) using phosphoryl chloride (2a), phenyl phosphoryl dichloride (2b), 4-chlorophenyl phosphoryl dichloride (2c) or phenylphosphonic dichloride (2d) in pyridine are reported.The chemical yield and melting point of 2-aminobenzonitrile (3a) obtained by four dehydrating reagents (2a-d) are listed in Table-1. 2-Aminobenzamide was dehydrated by reagents 2a-c to give 2-aminobenzonitrile in the yield lower than 60 %, while the reaction by reagent (2d) gave the highest yield, 96 %. On the other hand, benzamide (1b) without amino groups afforded benzonitrile (3a) in the yield of 43 %.synthesis of aminobenzonitrile by dehydration of aminobenzamide using phenylphosphonic dichloride in pyridine

Synthesis Reference(s)

Journal of the American Chemical Society, 96, p. 5933, 1974 DOI: 10.1021/ja00825a039The Journal of Organic Chemistry, 43, p. 944, 1978 DOI: 10.1021/jo00399a030Tetrahedron Letters, 32, p. 1007, 1991 DOI: 10.1016/S0040-4039(00)74473-X

Safety Profile

Poison by intravenous route. Seealso NITRILES. When heated to decomposition it emitstoxic fumes of NOx and CN- .

InChI:InChI=1/C7H6N2/c8-5-6-3-1-2-4-7(6)9/h1-4H,9H2

Synthetic route

o-nitrobenzonitrile (612-24-8) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With sodium tetrahydroborate In methanol; water at 20℃; for 0.0666667h; Sealed tube; Green chemistry; chemoselective reaction;	99%
With cyclohexa-1,4-diene; 5%-palladium/activated carbon In methanol at 120℃; for 0.0833333h; Microwave irradiation;	98%
With borane-ammonia complex In methanol; water at 20℃; for 0.166667h;	98%

anthranilic acid amide (28144-70-9) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With 3 Angstroem melecular sieves at 180 - 500℃; under 0.005 Torr; for 0.666667h; Pyrolysis;	99%
With thionyl chloride In toluene at 90 - 100℃;	91.6%
With oxalyl dichloride; 2,3-bis(4-methoxyphenyl)cyclopropenone; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane for 5h; Reflux;	89%
With vanadium oxide on hydrotalcite (V/HT) In 1,3,5-trimethyl-benzene for 24h; Reflux;	79%
With sieve-supported lead catalyst at 200℃; under 2250.23 Torr; for 0.3h;

sodium cyanide (773837-37-9) + 2-bromoaniline (615-36-1) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With tri-tert-butyl phosphine; [Pd2(dba)5]; zinc In tetrahydrofuran; acetonitrile at 70℃; for 2h;	99%

2-amino-1-benzylamine (4403-69-4) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With C68H64Cl2N6P2Ru2(4+)*2F6P(1-)*2Cl(1-); caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere; Green chemistry;	96.2%

potassium cyanide + 2-bromoaniline (615-36-1) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
Stage #1: potassium cyanide With acetic acid In ethylene glycol at 20℃; Sealed tube; Stage #2: 2-bromoaniline With P(t-Bu)3 Palladacycle Gen. 3; potassium acetate In 1,4-dioxane; water at 60℃; for 16h; Sealed tube;	95%

2-aminobenzaldehyde oxime (3398-07-0) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With eosin; carbon tetrabromide; N,N-dimethyl-formamide In acetonitrile at 25℃; for 14h; Irradiation; Inert atmosphere;	93%
Stage #1: 2-aminobenzaldehyde oxime With triethylamine In dichloromethane at 0 - 23℃; Inert atmosphere; Stage #2: With methanesulfonyl chloride In dichloromethane at 0 - 23℃; for 5h; Inert atmosphere;	69%
With formamide at 140 - 150℃;

2-azidobenzonitrile (31656-77-6) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With Decaborane; palladium on activated charcoal In methanol at 20℃; for 2.5h;	91%
With hexamethyldisilathiane In methanol for 1.5h; Ambient temperature;	90%
With dicobalt octacarbonyl In water at 20℃; for 5h;	87%
In decalin at 144℃; for 5h; Product distribution;
With 2,6-di-tert-butyl-4-methyl-phenol In decalin at 161.3℃; Rate constant; Kinetics; Thermodynamic data; ΔEact, ΔSact, other temperatures, other solvent;

triphenylphosphine (603-35-0) + N-(2-cyanophenyl)cyanothioformamide (174969-51-8) → 3-amino-1H-indole-2-carbonitrile (1192690-93-9) + anthranilic acid nitrile (1885-29-6)

Conditions	Yield
Stage #1: N-(2-cyanophenyl)cyanothioformamide With toluene-4-sulfonic acid In methanol at 20℃; for 0.0833333h; Stage #2: triphenylphosphine In methanol at 20℃; for 0.833333h;	A 90% B 8%

4-chloroquinazoline (5190-68-1) + phenylmagnesium bromide → benzaldehyde (100-52-7) + anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With hydrogenchloride multistep reaction; other arylmagnesium bromides; product yields;	A 89% B n/a

2-iodophenylamine (615-43-0) + K4[Fe(CN)6] → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With tetrabutylammomium bromide; sodium fluoride; palladium diacetate In water at 150℃; for 0.333333h;	88%

potassium hexacyanoferrate(III) trihydrate + 2-iodophenylamine (615-43-0) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With potassium phosphate In N,N-dimethyl-formamide at 120℃; for 2h;	88%

potassiumhexacyanoferrate(II) trihydrate + 2-iodophenylamine (615-43-0) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With palladium diacetate; sodium carbonate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride In N,N-dimethyl acetamide at 120℃; for 8h;	87%

potassiumhexacyanoferrate(II) trihydrate + 2-bromoaniline (615-36-1) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); tris(2-morpholinophenyl)phosphine; potassium carbonate In water; tert-butyl alcohol at 85℃; for 12h; Schlenk technique; Inert atmosphere;	84%
With sodium carbonate In water; N,N-dimethyl-formamide at 120℃; for 15h;	84%

2-Chlorobenzonitrile (873-32-5) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With ammonium hydroxide; copper(I) iodide; 1-ethylacetoacetate-3-methyl imidazolium hydroxide In acetonitrile at 120℃; for 12h; Inert atmosphere;	81%
With ((+/-)-binap)Ni[P(OPh)3]2; ammonia; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 1,4-dioxane at 120℃; for 18h; Sealed tube;	< 10 %Chromat.

o-cyanobromobenzene (2042-37-7) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With sodium azide; copper; L-proline In water; dimethyl sulfoxide at 150℃; under 37503.8 Torr; for 0.583333h; Flow reactor; chemoselective reaction;	79%

2-[4-oxo-3,4-dihydroquinazolin-3-yl]benzonitrile → 3-amino-3,4-dihydroquinazolin-4-one (14663-46-8) + anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With hydrazine dihydrochloride; triethylamine In methanol; N,N-dimethyl-formamide at 80℃; for 36h;	A 77% B n/a

2-iodophenylamine (615-43-0) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With ammonium cerium (IV) nitrate; copper(II) bis(trifluoromethanesulfonate); potassium carbonate at 130℃; for 24h;	75%

nitromethane (75-52-5) + o-nitroiodobenzene (609-73-4) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With 1,10-Phenanthroline; copper(II) nitrate trihydrate; potassium carbonate In dimethyl sulfoxide at 100℃; for 16h;	73%

2-bromoaniline (615-36-1) + malononitrile (109-77-3) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); sodium t-butanolate In N,N-dimethyl-formamide at 130℃; for 24h;	72%

benzo[c]isothiazol-3-ylamine (2400-12-6) → 2-(2'-aminophenyl)-4(3H)-quinazolinone (27259-73-0) + anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With sodium hydrogensulfite In water for 60h; Heating;	A 66% B 15%

2-iodobenzonitrile (4387-36-4) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With ammonium hydroxide; potassium phosphate; copper(II) ferrite at 100℃; for 12h; Sealed tube; chemoselective reaction;	64%

formamide (77287-34-4, 77287-35-5, 60100-09-6) + 2-bromoaniline (615-36-1) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; palladium on activated charcoal; potassium carbonate; triphenylphosphine at 25 - 130℃; for 12.1667h;	64%

propan-1-ol-3-amine (156-87-6) + 2-[4-oxo-3,4-dihydroquinazolin-3-yl]benzonitrile → 3-(3-hydroxypropyl)quinazolin-4(3H)-one + anthranilic acid nitrile (1885-29-6)

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 48h;	A 63% B n/a

2-iodophenylamine (615-43-0) + malononitrile (109-77-3) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With potassium fluoride; 1,10-Phenanthroline; copper diacetate; sodium t-butanolate In N,N-dimethyl-formamide at 120℃; for 18h;	60%

2-ethyl-N-hydroxy-2-methyl-2,3-dihydro-1H-indol-3-imine → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With thionyl chloride In dichloromethane	60%

o-nitrobenzonitrile (612-24-8) → anthranilic acid amide (28144-70-9) + anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With baker's yeast In ethanol; water at 32℃;	A 56% B 10%

methylamine (74-89-5) + 2-[4-oxo-3,4-dihydroquinazolin-3-yl]benzonitrile → 3-methylquinazolin-4(3H)-one (2436-66-0) + anthranilic acid nitrile (1885-29-6)

Conditions	Yield
In methanol; N,N-dimethyl-formamide at 20℃; for 10h;	A 56% B n/a

potassium ferrocyanide + 2-Chloroaniline (95-51-2) → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With 2-(dicyclohexylphosphino)-1-(2,6-diisopropylphenyl)-1H-imidazole; sodium carbonate; palladium dichloride In N,N-dimethyl acetamide at 140℃; for 16h; Inert atmosphere;	55%

N-acetyl isatin-β-oxime-O-acetate → anthranilic acid nitrile (1885-29-6)

Conditions	Yield
With sodium azide In acetonitrile for 20h; Heating;	53%

allylisocyanate (1476-23-9) + anthranilic acid nitrile (1885-29-6) → 2-(3-allylureido)benzonitrile (122372-27-4)

Conditions	Yield
for 48h; Ambient temperature;	100%
for 48h; Ambient temperature;	100%
In dichloromethane for 3h; Ambient temperature;	88%

anthranilic acid nitrile (1885-29-6) + Glycine ethyl ester isocyanate (2949-22-6) → 2-(3-ethoxycarbonylmethylureido)benzonitrile (78754-91-3)

Conditions	Yield
for 48h; Ambient temperature;	100%

rac-7-isopropylbicyclo[3.3.1]non-6-en-3-one (247591-83-9) + anthranilic acid nitrile (1885-29-6) → C19H22N2

Conditions	Yield
With aluminium trichloride In 1,2-dichloro-ethane for 12h; Condensation; Heating;	100%

5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione (15568-85-1) + anthranilic acid nitrile (1885-29-6) → 2-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}benzonitrile (1020252-22-5)

Conditions	Yield
In acetonitrile at 20℃; for 0.25h;	100%
In N,N-dimethyl-formamide for 2h; Heating;
In acetonitrile for 0.0333333h;

orthoformic acid triethyl ester (122-51-0) + anthranilic acid nitrile (1885-29-6) → ethyl (2-cyanophenyl)imidoformate (104326-76-3)

Conditions	Yield
for 0.75h; Reflux;	100%

m-anisoyl chloride (1711-05-3) + anthranilic acid nitrile (1885-29-6) → C15H12N2O2

Conditions	Yield
In pyridine at 0℃; for 4h;	100%

1,1,1-trifluoro-4,4-dimethoxy-but-3-en-2-one (1071146-39-8) + anthranilic acid nitrile (1885-29-6) → (E)-1,1,1-trifluoro-4-methoxy-4-(2-cyanophenyl)aminobut-3-en-2-one

Conditions	Yield
In acetonitrile for 18h; Reflux;	100%
In acetonitrile for 18h; Reflux;	100%

N,N-dimethyl-formamide (68-12-2, 33513-42-7) + anthranilic acid nitrile (1885-29-6) → 1,2,3,4-tetrahydro-quinazoline-2,4-dione (86-96-4)

Conditions	Yield
With carbon dioxide In water at 150℃; under 37503.8 Torr; for 5h;	99.2%
With zinc(II) chloride at 200℃; for 5h; sealed tube;	90%

benzaldehyde (100-52-7) + anthranilic acid nitrile (1885-29-6) → (E)-2-<(Phenylmethylene)amino>benzonitrile (125743-39-7)

Conditions	Yield
With 4 A molecular sieve In toluene at 23℃; for 10h;	99%
In toluene Schlenk technique; Inert atmosphere; Molecular sieve; Reflux;	89%
With toluene-4-sulfonic acid In toluene Reflux; Molecular sieve; Inert atmosphere; Schlenk technique;	89%

orthoformic acid triethyl ester (122-51-0) + anthranilic acid nitrile (1885-29-6) → N-ethoxymethylene-2-aminobenzonitrile (58314-88-8)

Conditions	Yield
In acetic acid; toluene at 100 - 110℃; for 3h;	99%
Heating;

3-Chloropropyl isocyanate (13010-19-0) + anthranilic acid nitrile (1885-29-6) → 2-<3-(3-Chloropropyl)ureido>benzonitrile (94507-24-1)

Conditions	Yield
Heating;	99%

anthranilic acid nitrile (1885-29-6) → 2,2'-(iminodimethylene)bisaniline (69084-37-3)

Conditions	Yield
With hydrogen In toluene at 90℃; under 750.075 Torr; for 20h; chemoselective reaction;	99%
With hydrogen; Rh/Al2O3

anthranilic acid nitrile (1885-29-6) → anthranilic acid amide (28144-70-9)

Conditions	Yield
With water; potassium carbonate at 150℃; for 0.5h; Microwave irradiation;	99%
With phosphate buffer at 30℃; for 1h; rhodococcus rhodocrous AJ270, pH 7.0;	98%
With potassium phosphate buffer at 30℃; for 1h; Rhodococcus sp. AJ270 cells;	97.7%

(S)-tert-leucinol (112245-13-3) + anthranilic acid nitrile (1885-29-6) → 2-[(4S)-4-(tert-butyl)-4,5-dihydro-1,3-oxazol-2-yl]aniline (194350-71-5)

Conditions	Yield
With zinc(II) chloride In chlorobenzene for 24h; Inert atmosphere; Reflux;	99%
With zinc(II) chloride In dichloromethane at 140℃; for 24h;	85%
With zinc(II) chloride In chlorobenzene at 130℃; for 36h;	82%

Triethyl orthopropionate (115-80-0) + anthranilic acid nitrile (1885-29-6) → ethyl N-(2-cyanophenyl)propanimidate (132121-43-8)

Conditions	Yield
With trifluoroacetic acid	99%

2-mercaptoethylamine hydrochloride (156-57-0) + anthranilic acid nitrile (1885-29-6) → 2-(4,5-dihydrothiazol-2-yl)aniline (1370477-92-1)

Conditions	Yield
With sodium hydroxide In neat (no solvent) at 80℃; for 2h;	99%
With sodium hydroxide at 80℃;	96%
With tetrakis(μ2-α-methacrylate-O,O')-bis(H2O)-dicopper(II); sodium acetate at 80℃; for 3.5h; Neat (no solvent);	92%

C14H14ClN2(1+)*CF3O3S(1-) + anthranilic acid nitrile (1885-29-6) → 2-(2-phenyl-4,5-dihydro-1H-imidazol-1-yl)benzonitrile

Conditions	Yield
In dichloromethane at 20℃; Inert atmosphere;	99%

anthranilic acid nitrile (1885-29-6) + N-ethyl-N-(2-cyanoethyl)aniline (148-87-8) → 2-{4-[(2-Cyano-ethyl)-ethyl-amino]-phenylazo}-benzonitrile (52547-43-0)

Conditions	Yield
Stage #1: anthranilic acid nitrile With sulfuric acid; nitrosyl sulphuric acid In water at 0 - 20℃; for 2h; Stage #2: N-ethyl-N-(2-cyanoethyl)aniline With sulfuric acid In water at 0℃; for 1h;	99%

3,4-dichloro-isothiazole-5-carbonyl chloride (56914-82-0) + anthranilic acid nitrile (1885-29-6) → isotianil (224049-04-1)

Conditions	Yield
In toluene at 80℃; for 2h; Solvent; Temperature;	98.8%
With pyridine In tetrahydrofuran at 5 - 20℃; for 1.25h; Product distribution / selectivity;	89%
With pyridine In tetrahydrofuran at 5 - 20℃; for 1.25h; Product distribution / selectivity;	89%
With pyridine In tetrahydrofuran; water; ethyl acetate; Petroleum ether

carbon dioxide (124-38-9) + anthranilic acid nitrile (1885-29-6) → 4-thioxo-1H,3H-quinazolin-2-one (17796-47-3)

Conditions	Yield
Stage #1: anthranilic acid nitrile With sodium hydrogen sulfide In N,N-dimethyl-formamide for 0.5h; Autoclave; Heating; Stage #2: carbon dioxide In N,N-dimethyl-formamide at 100℃; under 30003 Torr; for 24h; Reagent/catalyst; Temperature; Pressure; Solvent; Autoclave;	98.4%

anthranilic acid nitrile (1885-29-6) → 3,5-dibromoanthranilonitrile (68385-95-5)

Conditions	Yield
With bromine In acetic acid at 20℃;	98%
With bromine In acetic acid at 15 - 20℃; for 5h;	98%
With bromine; acetic acid at 15 - 20℃; for 5h; Cooling with ice;	98%

anthranilic acid nitrile (1885-29-6) → 2-amino-1-benzylamine (4403-69-4)

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran	98%
With [Ru(H)(BH4)(CO)(PPh3)(3-(di-tert-butylphosphino)-N-((1-methyl-1H-imidazol-2 yl)methyl)propylamine)]; hydrogen In isopropyl alcohol at 50℃; for 3h; Inert atmosphere; Autoclave;	98%
With C28H29Cl2CoNP2; hydrogen; sodium triethylborohydride In 1,4-dioxane at 80℃; under 37503.8 Torr; for 6h;	78%

cyclohexanone (108-94-1) + anthranilic acid nitrile (1885-29-6) → tacrin (321-64-2)

Conditions	Yield
With zinc(II) chloride at 120℃; for 16h;	98%
With silica gel; toluene-4-sulfonic acid for 0.133333h; microwave irradiation;	95%
With sulfuric acid-modified polyethylene glycol 6000 at 130℃; for 0.133333h; Friedlaender synthesis; Microwave irradiation; Neat (no solvent);	93%

diethyl 2-ethoxymethylenemalonate (87-13-8) + anthranilic acid nitrile (1885-29-6) → 8-cyano-3-ethoxycarbonyl-1,4-dihydro-4-oxoquinolone (127285-75-0)

Conditions	Yield
1.) 130 degC, 1-2 h, 2.) C6H5OC6H5, 250 degC, 1h;	98%
In diphenylether at 250℃; Gould-Jacobs condensation;	60%

anthranilic acid nitrile (1885-29-6) → 5-(2-aminophenyl)tetrazole (18216-38-1)

Conditions	Yield
With sodium azide In N,N-dimethyl-formamide at 120℃; for 4h;	98%
Stage #1: anthranilic acid nitrile With sodium azide In N,N-dimethyl-formamide at 120℃; for 36h; Stage #2: With hydrogenchloride In water; ethyl acetate for 0.0833333h;	95%
With iron(III) oxide; sodium azide In N,N-dimethyl-formamide at 120℃; for 36h;	92%

chloroacetyl chloride (79-04-9) + anthranilic acid nitrile (1885-29-6) → [(2-cyanophenyl)aminocarbonylmethyl]chloride (71993-21-0)

Conditions	Yield
With pyridine In N,N-dimethyl-formamide at 0 - 40℃; Microwave irradiation;	98%
With triethylamine In dichloromethane at 0 - 20℃; for 48h;	55%
With pyridine In N,N-dimethyl-formamide at 20℃; Acylation;	54%

Upstream product

• 188528-95-2 Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate 
• 188527-56-2 PYRIDINE, 2-PHENYL-5-(TRIFLUOROMETHYL)- 
• 188527-21-1 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 
• 188527-16-4 1-(4-BroMophenylsulfonyl)hoMopiperazine, 95% 
• 188527-14-2 4-(4-Benzyl-1-piperazinyl)-6-chloropyrimidine 
• 188527-10-8 1-benzyl-4-(piperidin-4-ylcarbonyl)piperazine 
• 188527-08-4 N-Benzyl 1-BOC-piperidine-4-carboxaMide 
• 188527-03-9 tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate 
• 188526-07-0 BETA-OXO-4-(TRIFLUOROMETHYL)-BENZENEPROPANOIC ACID PHENYLMETHYL ESTER 
• 188525-88-4 1,3-Dioxole-4-carboxylicacid,5-ethyl-2-oxo-(9CI) 
• 188525-85-1 1,3-Dioxol-2-one,4-(hydroxymethyl)-5-(1-methylethyl)-(9CI) 
• 188525-84-0 1,3-Dioxole-4-carboxylicacid,5-(1-methylethyl)-2-oxo-(9CI) 
• 188525-77-1 17-Methyl- 
• 188525-23-7 4-Oxa-1-azabicyclo[3.2.0]heptan-7-one,3-methyl-,(5S)-(9CI) 

Downstream Products

• 321-64-2 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE 
• 19808-35-6 6-CHLOROQUINAZOLIN-4-AMINE 
• 5922-60-1 2-Amino-5-chlorobenzonitrile 

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• 121998-76-3  2-phenyl-2,3-dihydro-4(1H)-quinazolinone 
• 100-52-7  benzaldehyde 
• 3265-35-8  indoline-2,3-dione-2-oxime 
• 612-24-8  o-nitrobenzonitrile 
• 1885-69-4  1,2-bis(2-cyanophenyl)diazene oxide 
• 861071-21-8  (2-cyano-phenyl)-oxalamic acid methyl ester 
• 553-90-2  Dimethyl oxalate 
• 85641-99-2  N,N'-bis-(2-cyano-phenyl)-oxalamide 
• 75-15-0  carbon disulfide 
• 75-44-5  phosgene 
• 462614-26-2  N-butyryl-anthranilonitrile 
• 106-31-0  butanoic acid anhydride 
• 491-36-1  4-Hydroxyquinazoline 
• 64-18-6  formic acid