188524-67-6

Basic information

• Product Name: 4-(4-Chloro-phenyl)-1H-pyrrole-3-carboxylic acid methyl ester
• Synonyms: 4-(4-Chloro-phenyl)-1H-pyrrole-3-carboxylic acid methyl ester
• CAS NO: 188524-67-6
• Molecular Weight: 235.67
• Mol File: 188524-67-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(4-Chloro-phenyl)-1H-pyrrole-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chloro-phenyl)-1H-pyrrole-3-carboxylic acid methyl ester(188524-67-6)
• EPA Substance Registry System: 4-(4-Chloro-phenyl)-1H-pyrrole-3-carboxylic acid methyl ester(188524-67-6)

Safety Data

• Hazardous Substances Data: 188524-67-6(Hazardous Substances Data)

Upstream product

• 7560-44-3 methyl 4-chlorocinnamate 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 

Downstream Products

• 122453-98-9 4-(4-Chloro-phenyl)-1H-pyrrole-3-carboxylic acid 

Relevant articles and documents

Solvent-controlled switchable C-H alkenylation of 4-aryl-1H-pyrrole-3-carboxylates: Application to the total synthesis of (±)-rhazinilam

A solvent-controlled switchable C-H alkenylation of 4-aryl-1H-pyrrole-3-carboxylates via a Pd(OAc)2 catalyzed oxidative Heck reaction was first realized. The corresponding C2 and C5 alkenylation products were obtained in good yields with high regioselectivities, respectively. The selective C5-alkenylation was successfully applied to the total synthesis of (±)-rhazinilam.

An efficient method for the synthesis of 3-arylpyrroles

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