188532-07-2

Upstream product

• 188532-05-0 [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(2,2-dimethyl-thiopropionylsulfanyl)-4-oxo-azetidin-1-yl]-oxo-acetic acid 4-nitro-benzyl ester 
• 188532-04-9 2,2-Dimethyl-dithiopropionic acid (2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl ester 
• 76899-07-5 (3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one 
• 81779-73-9 chloroxoacetic acid (4-nitrophenyl)methyl ester 
• 188532-06-1 (5R,6S)-3-tert-Butyl-6-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of (1'R, 5R, 6R)-2-tert-butyl-6-(1'-hydroxyethyl)penem-3-carboxylic acid

As with the oxapenems, the 2-tert-butyl substituents substantially increased the hydrolytic stability of penems. The corresponding penems 1 and 2 were prepared and found to be extremely stable compounds. 2 showed good in vitro activity against gram-positive bacteria.