188569-53-1Relevant academic research and scientific papers
First functionalization by metallation of the benzene moiety of quinazolines. Diazines XIX.
Ple, Nelly,Turck, Alain,Chapoulaud, Valerie,Queguiner, Guy
, p. 2871 - 2890 (2007/10/03)
The first lithiation on the benzene moiety of 4-substituted quinazolines has been highlighted. According to the nature and position of various directing groups, an exceptional regioselective metallation occured at position C8, peri to the N-1 ring nitrogen. This method allows an easy access to a large range of new substituted quinazolines.
