18861-16-0

Basic information

• Product Name: N-phenethyl-2-phenoxy-acetamide
• Synonyms: acetamide, 2-phenoxy-N-(2-phenylethyl)-
• CAS NO: 18861-16-0
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.3117
• Mol File: 18861-16-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 477.8°Cat760mmHg
• Flash Point: 242.8°C
• Appearance: /
• Density: 1.112g/cm³
• Vapor Pressure: 2.72E-09mmHg at 25°C
• Refractive Index: 1.566
• PKA: 14.56±0.46(Predicted)
• CAS DataBase Reference: N-phenethyl-2-phenoxy-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenethyl-2-phenoxy-acetamide(18861-16-0)
• EPA Substance Registry System: N-phenethyl-2-phenoxy-acetamide(18861-16-0)

Safety Data

• Hazardous Substances Data: 18861-16-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H17NO2/c18-16(13-19-15-9-5-2-6-10-15)17-12-11-14-7-3-1-4-8-14/h1-10H,11-13H2,(H,17,18)

Upstream product

• 64-04-0 phenethylamine 
• 122-59-8 2-phenoxyacetic acid 
• 701-99-5 Phenoxyacetyl chloride 

Relevant articles and documents

Efficient procedure for the preparation of amides using polymer-bound reagents

An effective method for the conversion of acids into amides is presented. The two-step procedure includes the preparation of acid chloride intermediates using Pol-Ph3P and subsequent treatment of these intermediates with amines and polymer-bound base. The amides were accessible in high yields and purities without further purification.

Electron-rich Triarylbismuthines as Selective Condensation Reagent under Neutral Conditions. Condensation of Aliphatic Carboxylic Acids with Amines and Alcohols

On heating with amines or alcohols in the presence of tris(2-methoxyphenyl)- or tris(2,6-dimethoxyphenyl)bismuthine, carboxylic acids bearing α-hydrogen are readily converted into the corresponding amides or esters in good yields while those without α-hydrogen remain intact.