188625-16-3

Upstream product

• 18638-99-8 3,4,5-trimethoxybenzylamine 
• 56074-21-6 N-((tert-butyloxy)carbonyl)iminodiacetic acid anhydride 
• 56074-20-5 N-((tert-butyloxy)carbonyl)iminodiacetic acid 

Downstream Products

• 206867-00-7 N-((tert-butoxy)carbonyl)-N'-((5-(benzyloxycarbonyl)amino-5-methoxycarbonyl)pentyl)-N''-(3,4,5-trimethoxybenzyl)iminodiacetic acid diamide 
• 211745-53-8 N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide 
• 737828-56-7 N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide 

Relevant academic research and scientific papers

PAIN-RELIEVING COMPOSITION

This invention relates to a composition for relieving pain, comprising the compounds of formula (I) or pharmaceutically acceptable salts thereof as an effective substance. The composition of the present invention relieves pain, particularly neuropathic pa

Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists

We describe the solution-phase combinatorial synthesis and pharmacological effect of fifty N,N′-substituted-N″-1-(4- chlorobenzhydryl)piperazine iminodiacetic acid triamide derivatives as nonpeptide B2 antagonists. The synthesized compounds wer

Solution-phase combinatorial synthesis: Convergent multiplication of diversity via the olefin metathesis reaction

The solution-phase synthesis of iminodiacetic acid diamides functionalized with ω-alkenes and their dimerization via the olefin metathesis reaction in the preparation of mixture libraries are detailed. Libraries containing as many as 113,232 compounds prepared from only N-BOC- iminodiacetic acid anhydride (1), 15 amines, and 4 ω-alkene carboxylic acids illustrate the diversity that may be achieved by a convergent versus divergent combination of a small number of monomer building blocks that provides the multiplication of diversity typically associated with linear library syntheses including peptides, oligonucleotides and sequential template functionalizations. Unlike the divergent synthesis of such libraries which is amenable to solid-phase synthesis techniques, the convergent synthesis is especially well suited for solution-phase synthesis and is precluded by solid-phase techniques since the combining components typically would be on mutually exclusive phases.

Solution-phase combinatorial synthesis via the olefin metathesis reaction

The preparation of C2-symmetric and unsymmetric chemical libraries by solution-phase techniques including the use of the olefin metathesis reaction to join and combinatorially randomize the length of a linking tether is detailed.