188625-17-4

Basic information

• Product Name: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-[2-[[2-(4-fluorophenyl)ethyl]amino]-2- oxoethyl]-
• CAS NO: 188625-17-4
• Molecular Formula: C17H23FN2O5
• Molecular Weight: 354.378
• Mol File: 188625-17-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-[2-[[2-(4-fluorophenyl)ethyl]amino]-2- oxoethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-[2-[[2-(4-fluorophenyl)ethyl]amino]-2- oxoethyl]-(188625-17-4)
• EPA Substance Registry System: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-[2-[[2-(4-fluorophenyl)ethyl]amino]-2- oxoethyl]-(188625-17-4)

Safety Data

• Hazardous Substances Data: 188625-17-4(Hazardous Substances Data)

Upstream product

• 1583-88-6 4-fluoro-2-phenethylamine 
• 56074-21-6 N-((tert-butyloxy)carbonyl)iminodiacetic acid anhydride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 56074-20-5 N-((tert-butyloxy)carbonyl)iminodiacetic acid 

Downstream Products

• 194996-28-6 N-((tert-butoxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(3,4,5-trimethoxybenzyl)iminodiacetic acid diamide 
• 194996-17-3 N-((tert-butoxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(3-(N-pyrrolidin-2-onyl)propyl)iminodiacetic acid diamide 
• 194996-11-7 {[2-(2,5-Dimethoxy-phenyl)-ethylcarbamoyl]-methyl}-{[2-(4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 194996-64-0 N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-((5-(benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)iminodiacetic acid diamide 
• 194996-58-2 (S)-2-Acetylamino-6-[2-(tert-butoxycarbonyl-{[2-(4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetylamino]-hexanoic acid methyl ester 
• 194996-22-0 {[2-(3,4-Dimethoxy-phenyl)-ethylcarbamoyl]-methyl}-{[2-(4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 194996-46-8 {[2-(4-Fluoro-phenyl)-ethylcarbamoyl]-methyl}-{[2-(2-hydroxy-ethoxy)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 211745-31-2 N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(2-(2'-thienyl)ethyl)iminodiacetic acid diamide 
• 211745-37-8 N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(furan-2-ylmethyl)iminodiacetic acid diamide 
• 211745-30-1 bis-{[2-(4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 211745-34-5 [2-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-2-oxo-ethyl]-{[2-(4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 211745-09-4 {[2-(4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-(phenethylcarbamoyl-methyl)-carbamic acid tert-butyl ester 
• 211745-26-5 {[2-(4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-{[2-(3-methoxy-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 331714-06-8 (S)-N-((tert-butyloxy)carbonyl)-N'-((4-fluorophenyl)ethyl)-N''-(5-methoxycarbonyl)-5-(((4-(trifluoromethyl)benzyloxycarbonyl)amino)pentyl)iminodiacetic acid monoamide 

Relevant articles and documents

Higher order iminodiacetic acid libraries for probing protein-protein interactions

Full details of the preparation of iminodiacetic acid diamide dimer (2040 compounds), trimer (560 compounds), and tetramer (1596 compounds) libraries by multistep convergent solution-phase synthesis for studying protein-protein interactions are provided. The libraries were assembled in a format providing small 8-10 compound mixtures and the deconvolution of many of the small mixtures to identify screening leads by resynthesis of the individual components have been conducted for 320 of the individual compounds to date. A representative example of the subsequent exploration of the structure-activity relationships for an identified receptor binding antagonist (200 additional individual compounds) and steps taken for potential elaboration to a receptor dimerization agonist are defined with preparation of representative linked dimers (70 compounds). Copyright (C) 1998 Elsevier Science Ltd.

Higher order iminodiacetic acid libraries for probing protein-protein interactions

Higher order iminodiacetic acid diamide trimer (560 compounds) and tetramer libraries (1260 compounds) are described and were assembled in a convergent multistep solution-phase synthesis for use in studying protein- protein interactions.

Generation of targeted C2-symmetrical compound libraries by solution-phase combinatorial chemistry

An approach to the preparation of C2-symmetrical chemical libraries for use in protein and receptor homodimerization studies by solution-phase methods which permits the multi-milligram synthesis of each member is described.